Evidence map›Paper›PMID 41797926›Full record

ArticleiScience2026

Dopamine enhances surface glial glycolysis via acetylcholine and insulin/insulin-like growth factor signaling in the honeybee.

Miaoran Zhang, Xingan Li, Yunxiao Zhang, Huanyu Zhang, Meng Xu, Jieluan Li, Qingsheng Niu, Wei Feng, Aowen Tian, Peng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miaoran ZhangKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China.
Xingan LiKey Laboratory for Bee Genetics and Breeding, Jilin Provincial Institute of Apicultural Sciences, Jilin, Jilin Province, China.
Yunxiao ZhangKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China.
Huanyu ZhangKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China.
Meng XuKey Laboratory for Bee Genetics and Breeding, Jilin Provincial Institute of Apicultural Sciences, Jilin, Jilin Province, China.
Jieluan LiKey Laboratory for Bee Genetics and Breeding, Jilin Provincial Institute of Apicultural Sciences, Jilin, Jilin Province, China.
Qingsheng NiuKey Laboratory for Bee Genetics and Breeding, Jilin Provincial Institute of Apicultural Sciences, Jilin, Jilin Province, China.
Wei FengKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China.
Aowen TianDepartment of Geriatrics, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, China.
Peng ChenKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolysis plays a crucial role in neuronal homeostasis and is regulated by neuroendocrine signals, particularly dopamine, yet the underlying mechanisms remain unclear. Metabolomics showed that bromocriptine (BRC), a dopamine receptor agonist, increased glycolytic flux in forager bees, as indicated by higher glucose levels, accumulation of glycolytic intermediates, and reduced pentose-phosphate pathway metabolites. Single-cell and single-nucleus RNA-seq further indicated that acetylcholine (ACh) released by Kenyon cells may mediate dopamine-regulated glycolysis in surface glia (SG). We also observed coordinated insulin/insulin-like growth factor signaling (IIS) between cortex glia (CG) and SG. Mechanistically, co-administration of a nicotinic ACh receptor agonist with BRC attenuated the BRC-induced upregulation of

Indexed as

EntomologyMolecular biologyNeuroscience

Identifiers

PMID41797926
PMCPMC12964235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.