Evidence map›Paper›PMID 41797866›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Delphi consensus guidelines for the use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy for the diagnosis of dementia and mild cognitive impairment with Lewy bodies.

Paul C Donaghy, Gemma Greenfinch, George Petrides, Joseph Kane, Hein J Verberne, John-Paul Taylor, John T O'Brien, Alan J Thomas, DLB Indicative Imaging Biomarker Study Group

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul C DonaghyTranslational and Clinical Research Institute and NIHR Newcastle Biomedical Research Centre Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0001-7195-4846
Gemma GreenfinchInstitute of Nuclear Medicine University College London Hospitals London UK.
George PetridesDepartment of Nuclear Medicine Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK.
Joseph KaneCentre for Public Health Queen's University Belfast Institute of Clinical Sciences Royal Victoria Hospital Belfast UK.
Hein J VerberneDepartment of Radiology and Nuclear Medicine Amsterdam UMC Amsterdam the Netherlands.
John-Paul TaylorTranslational and Clinical Research Institute and NIHR Newcastle Biomedical Research Centre Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK.
John T O'BrienDepartment of Old Age Psychiatry School of Clinical Medicine Cambridge University Cambridge Biomedical Campus Cambridge UK.
Alan J ThomasTranslational and Clinical Research Institute and NIHR Newcastle Biomedical Research Centre Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK.
DLB Indicative Imaging Biomarker Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this Delphi process was to develop consensus guidelines to support the effective use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy in the diagnosis of dementia with Lewy bodies and mild cognitive impairment with Lewy bodies.

methodsA Delphi consensus panel of 37 international experts independently indicated their agreement or disagreement with statements on indications for the use of these biomarkers and clinical situations in which each biomarker should and should not be used. Statements were accepted if they reached > 80% agreement.

resultsOverall, 36/70 statements (51%) were accepted in Round 1, and 19/37 (51%) were accepted in Round 2. DISCUSSION: The Delphi consensus process has developed freely available guidelines outlining clinical situations in which striatal dopaminergic imaging and cardiac MIBG scintigraphy may be useful and considerations for their use, including the effect of specific comorbidities and medications on each of the biomarkers.

Indexed as

dementia with Lewy bodiesimagingioflupanemetaiodobenzylguanidinemild cognitive impairment with Lewy bodies

Identifiers

PMID41797866
PMCPMC12960062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.