ArticleOrthopedic reviews2026
Pharmacologic Management of Neuropathic Pain After Lumbar Spine Surgery: A Case-Based Review.
Article in Orthopedic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Postoperative Sciatic Neuropathy Following Ankle Surgery and Peripheral Nerve Blockade: A Case-Based Review.Orthopedic reviews · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic neuropathic pain following lumbar spine surgery remains a common and challenging clinical problem in pain medicine, often persisting despite surgical intervention and injections. This case-based educational review describes a 62-year-old man with multiple prior lumbar surgeries who developed persistent bilateral lower-extremity neuropathic pain consistent with persistent pain after spinal surgery. Initial treatment with gabapentin, titrated to therapeutic doses, resulted in minimal clinical improvement, prompting transition to pregabalin with moderate symptom relief. The addition of tramadol for breakthrough pain further improved functional status and sleep quality. Through this clinical scenario, key pharmacologic principles are reviewed, including the mechanisms of action, pharmacokinetics, safety considerations, and practical differences between gabapentin and pregabalin, as well as the role of tramadol as a dual-mechanism analgesic for mixed neuropathic and nociceptive pain. This teaching case is of particular educational value for trainees in orthopedics, pain management, anesthesiology, and primary care, where stepwise pharmacologic decision-making and longitudinal management of complex post-surgical pain syndromes are frequently encountered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.