Trial reportFrontiers in medicine2026
Effects of different doses of alfentanil on tracheal intubation stress responses in ambulatory hysteroscopic surgery: a randomized, double-blind, clinical comparative study.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This randomized, double-blind, clinical comparative study aims to compare the tracheal intubation stress responses of different doses of alfentanil in anesthesia induction for ambulatory hysteroscopic surgery, as well as their impact on the quality of early postoperative recovery. Methods: This study enrolled a total of 160 patients aged 20-60 years scheduled for ambulatory hysteroscopic surgery. All patients underwent tracheal intubation under general anesthesia and were randomly allocated into four groups using a random number table. The low-dose alfentanil group (group AL) patients received an induction dose of 20 μg/kg alfentanil, the medium-dose alfentanil group (group AM) patients received 30 μg/kg alfentanil, the high-dose alfentanil group (group AH) received 40 μg/kg alfentanil, and the Fentanyl Group (group F) patients received an induction dose of 4 μg/kg fentanyl, with all groups additionally administered midazolam, cisatracurium, and propofol as part of the standardized induction protocol. Anesthesia maintenance was maintained with propofol and remifentanil in all groups. The primary outcome measure was the plasma norepinephrine (NE) level at 1 min after tracheal intubation (T Results: The levels of plasma NE and E in group AL were significantly higher than that in group F at T Conclusion: In ambulatory hysteroscopic surgery, intravenous 30 μg/kg and 40 μg/kg alfentanil inhibited the stress reaction caused by tracheal intubation, alleviated hemodynamic fluctuations, and decreased the intensity of postoperative pain. However, 40 μg/kg alfentanil significantly increased the incidence of hypotension and bradycardia from anesthesia induction to 5 min after tracheal intubation. Therefore, 30 μg/kg alfentanil may be more suitable for the application of ambulatory hysteroscopic surgery. Clinical trial registration: https://www.chictr.org.cn, ChiCTR2300073590.
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