SynthesisFrontiers in medicine2026
Risk factors for depression in systemic lupus erythematosus: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Depression is highly prevalent among patients with systemic lupus erythematosus (SLE) and is associated with adverse clinical outcomes. However, evidence on its risk factors remains inconsistent, limiting early identification and targeted intervention. Methods: We conducted a systematic review and meta-analysis in accordance with PRISMA and MOOSE guidelines. Eight databases were searched from inception to May 2024 for observational studies reporting risk factors for depression in adult SLE patients assessed by validated scales. Study quality was evaluated using the Newcastle-Ottawa Scale or AHRQ criteria. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. Results: A total of 26 studies ( Conclusion: This meta-analysis identifies key clinical, demographic, and psychosocial risk factors for depression in SLE. Findings support integrating routine depression screening with holistic assessments of disease burden and social context in clinical practice, particularly within nursing-led care models. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024557892, identifier CRD42024557892.
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