SynthesisFrontiers in medicine2026
The efficacy of platelet-rich fibrin in alveolar ridge preservation: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Component network meta-analysis of scaffold materials, platelet-rich fibrin and barrier membranes for alveolar ridge preservation.Frontiers in oral health · 2026Pooled it
- The potential of eggshell membrane in bone regeneration: a scoping review of applications and advances.The Saudi dental journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The aim of this study was to systematically evaluate the independent efficacy of platelet-rich fibrin (PRF) as a sole grafting material in alveolar ridge preservation and to dynamically delineate the trajectory of PRF's effects on alveolar ridge morphology and new bone formation across various healing stages. Methods: A comprehensive search was conducted across four databases (PubMed, Embase, the Cochrane Library, and Web of Science) for pertinent records from their establishment until November 2025. The study encompassed randomized controlled trials (RCTs) that evaluated alveolar ridge preservation utilizing PRF alone in comparison to spontaneous healing. Two investigators independently conducted literature screening, data extraction, and methodological quality evaluation, employing the Cochrane Risk of Bias instrument (ROB-2) for the latter. The certainty of the evidence for each outcome was assessed using the GRADE framework. The meta-analysis utilized RevMan version 5.3, while publication bias was evaluated by Egger's test in Stata 18. Results: A total of eighteen studies were incorporated into the analysis. Compared to the spontaneous healing group, the PRF group showed significantly smaller losses in alveolar bone height at 3 months ( Conclusion: PRF appears to mitigate alveolar bone resorption following tooth extraction and may enhance new bone formation during the healing process. The osteogenic effect of PRF may be optimized by high-speed centrifugation protocols. As a secure autologous biomaterial, it is a promising option for preserving alveolar bone and enhancing circumstances for eventual implant restoration. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251183872, identifier PROSPERO (CRD420251183872).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.