Evidence map›Paper›PMID 41797737›Full record

ArticleClinical case reports2026

Hereditary Thrombotic Thrombocytopenic Purpura Associated With Recurrent Strokes and Prominent Nervous System Involvement in a Young Chinese Female.

Wanying Liu, Jiaying Wu, Xi Ming, Qi Zhang, Delian Zhou, Rubing Zheng, Mi Zhou, Zhen Shang, Liting Chen, Xiaojian Zhu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wanying LiuDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID https://orcid.org/0000-0001-8552-2665
Jiaying WuDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Xi MingDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Qi ZhangDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID https://orcid.org/0000-0002-2440-4451
Delian ZhouDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Rubing ZhengDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Mi ZhouDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Zhen ShangDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Liting ChenDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Xiaojian ZhuDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Yi XiaoDepartment of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive inherited disease caused by an ADAMTS1 gene mutation, resulting in absence or severe deficiency of plasma ADAMTS13 activity. The common causes include infection, inflammation, or pregnancy. Here, we present a case involving a 30 year old female with hereditary TTP, identified as compound heterozygous mutations of ADAMTS13 c.1045C > T (p.Arg349Cys) and c.2411G > A (p.Cys804Tyr). Our findings suggest that patients with these mutations are prone to recurrent strokes and exhibit prominent neurological symptoms.

Indexed as

ADAMTS13hereditarystrokethrombotic thrombocytopenic purpura

Identifiers

PMID41797737
PMCPMC12961529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.