Evidence map›Paper›PMID 41797703›Full record

ArticleCirculation2026

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Yongneng Zhang, Sébastien Bonnet, Steeve Provencher, Jiyuan Piao, Alois Haromy, Yongsheng Liu, Yuan-Yuan Zhao, Sandra Breuils-Bonnet, Sarah-Eve Lemay, Dawn E Bowles and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yongneng ZhangDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).ORCID 0000-0002-0791-9381
Sébastien BonnetPulmonary Hypertension and Vascular Biology Research Group CRIUCPQ, Department of Medicine, Laval University, Quebec, Canada (S.B., S.P., S.B.-B., S.-E.L.).ORCID 0000-0001-5753-1900
Steeve ProvencherPulmonary Hypertension and Vascular Biology Research Group CRIUCPQ, Department of Medicine, Laval University, Quebec, Canada (S.B., S.P., S.B.-B., S.-E.L.).ORCID 0000-0001-7535-9972
Jiyuan PiaoDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).ORCID 0000-0002-4435-7285
Alois HaromyDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).ORCID 0000-0003-4744-9879
Yongsheng LiuDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).
Yuan-Yuan ZhaoDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).
Sandra Breuils-BonnetPulmonary Hypertension and Vascular Biology Research Group CRIUCPQ, Department of Medicine, Laval University, Quebec, Canada (S.B., S.P., S.B.-B., S.-E.L.).
Sarah-Eve LemayPulmonary Hypertension and Vascular Biology Research Group CRIUCPQ, Department of Medicine, Laval University, Quebec, Canada (S.B., S.P., S.B.-B., S.-E.L.).ORCID 0000-0002-6625-9918
Dawn E BowlesDepartment of Surgery, Duke University Medical Center, Durham, NC(D.E.B., M.M.P.).
Michelle Mendiola PlaDepartment of Surgery, Duke University Medical Center, Durham, NC(D.E.B., M.M.P.).ORCID 0000-0001-9348-7708
Gopinath SutendraDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).ORCID 0000-0002-8181-1483
Evangelos D MichelakisDepartment of Medicine (Cardiology), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Y.Z., J.P., A.H., Y.L., Y.-Y.Z., G.S., E.D.M.).ORCID 0000-0003-0787-7721

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular failure drives both morbidity and mortality in pulmonary arterial hypertension (PAH), but the mechanism of transition from compensated right ventricle (cRV) to decompensated RV (dRV) is unknown, and some PAH patients develop dRV faster than others.

methodsWe explored the role of RV cardiac myofibroblasts (cMFBs) on this transition utilizing 2 rat models: monocrotaline (MCT) versus the less inflammatory pulmonary artery banding (PAB); and 3 patient cohorts (n=81) of PAH versus group 2 pulmonary hypertension (PHT-2). We hypothesized that loss of UCP2 (uncoupling protein 2), critical for mitochondrial calcium (mCa

resultsWe separated rat cRV from dRV based on catheterization and echocardiographic criteria and found a significant increase in cMFBs from MCT but not PAB RV (which decompensated much later than MCT RV). In isolated hearts, MCT RV contractility was lower in dRV but not in isolated cardiomyocytes (CMs), pointing to a non-CM cause. Mitochondrial respiration was lower in MCT dRV cMFBs than in control and cRV cFBs but increased in MCT-RV CMs. mCa

conclusionsOur data suggest that a change of cell identity (cFBs to cMFBs) in the RV is a driver of RV decompensation. TNF-α or rs659366 is a potential biomarker for early RV decompensation in PAH.

Indexed as

Heart FailureHypertension, PulmonaryMyofibroblastsPolymorphism, Single NucleotideUncoupling Protein 2Ventricular Dysfunction, RightAnimalsCells, CulturedDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRatsRats, Sprague-DawleyUCP2 protein, humanUcp2 protein, ratUncoupling Protein 2calciumheart failurehypertension, pulmonaryhypertrophy, right ventricularmyofibroblaststumor necrosis factor-alphauncoupling protein 2

Identifiers

PMID41797703
PMCPMC13166053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.