ReviewSmall (Weinheim an der Bergstrasse, Germany)2026
Conundrums of Localized Surface Plasmon Resonance Biosensors.
Review in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Strategies for Multiplexing Plasmonic Biosensing.Sensors (Basel, Switzerland) · 2026Review
- Reconfigurable Nanogap SERS for Multiscale Molecular Sensing on Curved Surfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Localized surface plasmon resonance (LSPR) biosensing offers label-free, real-time detection of biomolecular interactions with high sensitivity and compact instrumentation. However, despite widespread use, several persistent and poorly understood phenomena limit the reproducibility, quantitation, and interpretability of LSPR signals. This perspective examines six recurring "conundrums" in LSPR biosensing, with a focus on their physical origins, experimental manifestations, and current approaches to mitigation. I review puzzling cases where analyte binding induces either red or blueshifts of the plasmon resonance; the difficulty of isolating the surface-confined signal from bulk refractive-index drift in microfluidics; the finite decay length of the plasmon field and the resulting saturation for thick or inhomogeneous layers; environmental cross-sensitivities to temperature, pH, and ionic strength; run-to-run variability in nanostructure fabrication; and spectral congestion in multiplexed measurements. For each, I discuss the state of understanding, identify open questions, and outline strategies from advanced optical readouts to algorithmic baseline correction that could enable truly quantitative, drift-immune, and reproducible LSPR biosensing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.