Evidence map›Paper›PMID 41797670›Full record

ArticleOrganic & biomolecular chemistry2026

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors.

Arun K Ghosh, Amlan Bhattacharjee, Uttara Jayashankar, Sydney N Bogan, Andrew D Mesecar

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arun K GhoshDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu.ORCID 0000-0003-2472-1841
Amlan BhattacharjeeDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu.
Uttara JayashankarDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-7655-8671
Sydney N BoganDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-8710-8185
Andrew D MesecarDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
SARS-CoV-2 protease inhibitors for treating COVID-19R01AI158649 · NIAID · PURDUE UNIVERSITY · PI ARUN K GHOSH, ANDREW D MESECAR · 2021 to 2026
$3.8M
Design & Synthesis of Nonpeptide Protease InhibitorsR01AI150466 · NIAID · PURDUE UNIVERSITY · PI ARUN K GHOSH · 2023 to 2026
$2.4M
Purdue University Molecular Biophysics Training ProgramT32GM132024 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon, John Tesmer · 2019 to 2026
$2.0M
Design & Synthesis of Nonpeptide Protease InhibitorsR37AI150466 · NIAID · PURDUE UNIVERSITY · PI GHOSH, ARUN K · 2019 to 2020
$969k
Drug Discovery in Infectious Disease TrainingT32AI148103 · NIAID · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL, YEO, YOON · 2020 to 2024
$949k
New X-ray Diffractometer and Detector for Purdue Macromolecular CrystallographyS10OD030507 · OD · PURDUE UNIVERSITY · PI TESMER, JOHN · 2022 to 2022
$860k
NCI NIH HHS P30 CA023168NIAID NIH HHS HHSN272201700060CNIAID NIH HHS R01 AI150466NIAID NIH HHS R01 AI158649NIAID NIH HHS R37 AI150466NIAID NIH HHS T32 AI148103NIGMS NIH HHS T32 GM132024NIH HHS S10 OD030507
6 · The paper itself

Abstract

We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective tools for generation of Ugi products. Ugi reactions using either chiral aldehyde or chiral amine provided bis-amide derivatives with marginal diastereoselectivity. However, the reaction with a matched combination of (

Indexed as

AldehydesAmidesAntiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsSARS-CoV-2HumansMolecular StructureStereoisomerismAldehydesAmidesAntiviral AgentsCoronavirus 3C ProteasesProtease Inhibitors

Identifiers

PMID41797670
PMCPMC12969283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.