Evidence map›Paper›PMID 41797512›Full record

ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2026

Age-specific melanoma risk associated with melanocytic nevi: a pooled analysis from the M-SKIP project.

Giulia Doi, Aurora Gaeta, Simone Ribero, Nelleke Gruis, Julia Newton-Bishop, David Polsky, DeAnn Lazovich, Paola Ghiorzo, Gloria Ribas, Chiara Menin and 11 more

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Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Giulia DoiMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0009-0001-2332-9218
Aurora GaetaMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Simone RiberoDepartment of Medical Sciences, Dermatologic Clinic University of Turin, Turin, Italy.
Nelleke GruisDepartment of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Julia Newton-BishopInstitute of Medical Research at St James's, University of Leeds, Leeds, UK.
David PolskyRonald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, NYU Langone Health, New York, USA.
DeAnn LazovichDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Paola GhiorzoDepartment of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.
Gloria RibasDpdt. Oncologia medica y hematologia, Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria- INCLIVA, Valencia, Spain.
Chiara MeninDiagnostic Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy.
Alexander J Stratigos1st Clinic of Dermatological and Venereal Diseases, Medical School National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athina, Greece.
Gabriella GuidaDepartment of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari "A. Moro", Bari, Italy.
Susana PuigMelanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Spain.
Maria Concetta FargnoliSan Gallicano Dermatological Institute - IRCCS, Rome, Italy.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-5567-9618
Paola QueiroloMelanoma, Sarcoma and Rare Tumors Oncology Department, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Vincenzo BagnardiDepartment of Statistics and Quantitative Methods, University of Milan-Bicocca, Italy.
Veronique BatailleTwin Unit and genetic epidemiology department, King's College London, London, UK.
Sara RaimondiMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Sara GandiniMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
M‐SKIP study group

Funding

IEO
6 · The paper itself

Abstract

objectiveThis study investigates the association of melanoma risk with total-body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals.

methodsA pooled analysis was conducted within the M-SKIP project, based on multiple melanoma case-control studies. Associations were assessed through study-specific odds ratios (ORs), adjusted for potential confounders.

resultsNine case-control studies were included, analyzing common nevi (2,674 melanoma cases/2,343 controls) and atypical nevi (2,459 cases/1,740 controls). High common nevus count was associated with increased melanoma risk in both younger (summary [s]OR = 2.56; 95% CI 1.64-4.01; I

conclusionsThese findings suggest age-specific differences in melanoma risk associated with nevus burden. Specifically, atypical nevi are a stronger risk factor in younger individuals. This could have significant implications for prevention strategies and clinical management, in particular for better identification of high-risk groups for targeted secondary prevention efforts.

Indexed as

MelanomaNevus, PigmentedSkin NeoplasmsAdultAgedAge DistributionCase-Control StudiesFemaleGermanyHumansMaleMiddle AgedRisk AssessmentRisk FactorsYoung AdultAgeMC1Rmelanomaneviprimary and secondary prevention

Identifiers

PMID41797512
PMCPMC13551166

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.