Evidence map›Paper›PMID 41797299›Full record

ArticleOncoimmunology2026

KRAS-elicited PDIA6 blocks PERK-dependent immunogenic cell death in pancreatic carcinoma.

Liwei Zhao, Peng Liu, Guido Kroemer, Oliver Kepp

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liwei ZhaoInstitut Universitaire de France, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université Paris Cité, Paris, France.ORCID 0000-0001-5077-327X
Peng LiuInstitut Universitaire de France, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université Paris Cité, Paris, France.ORCID 0000-0002-1682-9222
Guido KroemerInstitut Universitaire de France, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université Paris Cité, Paris, France.ORCID 0000-0002-9334-4405
Oliver KeppInstitut Universitaire de France, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université Paris Cité, Paris, France.ORCID 0000-0002-6081-9558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) remains largely refractory to immune checkpoint blockade. Wang et al. identified PDIA6 as a KRAS-driven suppressor of PERK-dependent immunogenic cell death, fostering immune exclusion. PDIA6 inhibition restores CD8

Indexed as

Carcinoma, Pancreatic DuctaleIF-2 KinaseImmunogenic Cell DeathPancreatic NeoplasmsProtein Disulfide-IsomerasesProto-Oncogene Proteins p21(ras)AnimalsHumansImmunotherapyEIF2AK3 protein, humaneIF-2 KinaseKRAS protein, humanPDIA6 protein, humanProtein Disulfide-IsomerasesProto-Oncogene Proteins p21(ras)Cancer immunotherapycell stressimmune exclusionsmall molecule

Identifiers

PMID41797299
PMCPMC12973465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.