Evidence map›Paper›PMID 41797295›Full record

ReviewClinical anatomy (New York, N.Y.)2026

Innervation of the Maxillary Teeth: Integrating Classical Anatomy With the Dual Innervation Model.

Kiyosato Hino, Shogo Kikuta, Shion Hama, Yuliya M Melnichenko, Norio Kitagawa, Jingo Kusukawa, Sergey L Kabak, Nicolás E Ottone, Carlos A Suarez-Quian, R Shane Tubbs and 1 more

Abstract readReview
In one paragraph

Review in Clinical anatomy (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kiyosato HinoDental and Oral Medical Center, Kurume University School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0003-4806-4823
Shogo KikutaDental and Oral Medical Center, Kurume University School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-2236-2884
Shion HamaSection of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Yuliya M MelnichenkoHuman Morphology Department, Belarusian State Medical University, Minsk, Belarus.ORCID https://orcid.org/0000-0002-5652-7296
Norio KitagawaDepartment of Oral and Maxillofacial Anatomy, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Jingo KusukawaDental and Oral Medical Center, Kurume University School of Medicine, Fukuoka, Japan.
Sergey L KabakHuman Morphology Department, Belarusian State Medical University, Minsk, Belarus.ORCID https://orcid.org/0000-0002-7173-1818
Nicolás E OttoneLaboratory of Plastination and Anatomical Techniques, Universidad de La Frontera, Temuco, Chile.
Carlos A Suarez-QuianDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
R Shane TubbsDepartment of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Joe IwanagaDental and Oral Medical Center, Kurume University School of Medicine, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-8502-7952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A precise understanding of maxillary tooth innervation is paramount for all dental and oral surgical procedures, from routine local anesthesia to complex interventions. The three superior alveolar nerves-posterior, middle, and anterior-arise from the maxillary division of the trigeminal nerve, forming the superior dental plexus that classically innervates the maxillary teeth. However, this conventional anatomical paradigm has often failed to fully explain common clinical phenomena, such as the inconsistent efficacy of specific anesthetic techniques or the unpredictable outcomes observed in practice. Recent groundbreaking advancements in diagnostic imaging and microanatomical research have provided critical insights, addressing these long-standing clinical questions. This review comprehensively synthesizes classical anatomical knowledge with these contemporary findings. It establishes a dual innervation model that reveals a significant neurovascular supply originating from the palatal aspect, a pathway previously unhighlighted yet complementary to the well-known buccal pathways. Furthermore, it necessitates a reassessment of established palatal anesthetic techniques, such as the anterior and middle superior alveolar (AMSA) and the palatal approach anterior superior alveolar (P-ASA) nerve blocks, identifying them as localized palatal infiltrations rather than true nerve blocks. This new anatomical perspective has led to the proposal of evidence-based techniques, such as the palatal alveolar foramen injection (PAFI). Integrating this comprehensive dual innervation concept into future anatomical education and clinical training is essential to enhance surgical precision and ultimately bring greater benefits to patients.

Indexed as

MaxillaMaxillary NerveToothTrigeminal NerveHumansNerve Blockanatomyanesthesialocal anesthesiamaxillamaxillary nervepainsuperior alveolar nervessuperior dental plexustoothtrigeminal nerve

Identifiers

PMID41797295
PMCPMC13472278

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.