ArticleJournal of dental research2026
Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.
R A Kamath, A Phanrungsuwan, C Ge, S Shahid, F F Mohamed, J Chung, Y Han, M Killian, V Kaartinen, B L Foster and 1 more
Abstract read
In one paragraphArticle in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
R A KamathDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
A PhanrungsuwanDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
C GeDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
S ShahidDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
F F MohamedDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
J ChungDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Y HanDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
M KillianOrthopaedic Research Laboratory, University of Michigan School of Medicine, Ann Arbor, MI, USA.
V KaartinenDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0002-9432-510X B L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-3444-0576 R T FranceschiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0003-1405-2541 Funding
Discoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4MFunctions of extracellular matrix proteins in dental and skeletal mineralizationR01DE027639 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2019 to 2026
$2.3MFGF signaling during growth and mechanical adaptation of tendon-bone interfacesR01AR079367 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KILLIAN, MEGAN L. · 2021 to 2025
$2.0MNIAMS NIH HHS R01 AR079367NIDCR NIH HHS R01 DE027639NIDCR NIH HHS R01 DE029465
6 · The paper itselfAbstract
Discoidin Domain Receptor 2 (DDR2) is a collagen-activated tyrosine kinase required for bone and tooth development as well as regeneration of calvarial and long bones. Although DDR2 is expressed in alveolar bone, its functions in this site have not been previously examined. The present study used global and conditional knockout approaches and lineage tracing to examine the functions of DDR2 in alveolar bone formation during tooth socket healing. First molars were extracted from the maxillae of wild-type and globally
Indexed as
bone biologybone remodeling and regenerationcell-matrix interactionscollagenscraniofacial biology and geneticsextracellular matrix
Identifiers
PMID41797269
PMCPMC13133980
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