Evidence map›Paper›PMID 41797048›Full record

ArticleEBioMedicine2026

Circadian rhythm disruption impairs ovarian follicular development via NAD

Yan-Yun Ying, Xin Chen, Sen-Yi Yao, Rui-Xue Chen, Yue Ying, Hong Qiu, Qi-Qi Xu, Zheng-Yi Li, Cun-Qi Ye, Yu-Li Qian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yan-Yun YingInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Xin ChenInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Sen-Yi YaoInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Rui-Xue ChenInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Yue YingInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Hong QiuZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310006, China.
Qi-Qi XuInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Zheng-Yi LiDivision of Human Reproduction and Developmental Genetics, Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Cun-Qi YeZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310006, China.
Yu-Li QianInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China.
Hong-Qing LiangInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China; Division of Human Reproduction and Developmental Genetics, Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, 310006, China. Electronic address: lianghongqing@zju.edu.cn.
Xiao SunInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China; Zhejiang Provincial Clinical Research Center for Child Health, Hangzhou, 310006, China. Electronic address: xiaosun@zju.edu.cn.
Dan ZhangInstitute of Medical Genetics and Development, and Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, 310006, China; Zhejiang Provincial Clinical Research Center for Child Health, Hangzhou, 310006, China. Electronic address: zhangdan@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircadian rhythms play a crucial role in human health, including reproductive health. Disruption of circadian rhythm is associated with female infertility. However, how circadian disruption affects ovarian function remains unclear. The main purpose of this study is to verify the impact of long-photoperiod exposure on follicular development and ovarian function.

methodsIn this study, we employed long-photoperiod (LP) conditions (18 h lightness/6 h darkness) in rats to mimic increased light exposure in human lifestyles. Hormone indicators, oestrus cycle, ovary morphology, follicular development and ovulation were used to validate the ovarian function. To investigate the underlying mechanisms, a series of experiments, including RNA sequencing, metabolomics, ChIP/qPCR, transmission electron microscopy, immunofluorescence, and western blotting, were conducted. Additionally, the impact of nicotinamide mononucleotide (NMN) on ovarian function was evaluated using the mentioned methods above.

findingsLP exposure reduced the number of growing ovarian follicles and retrieved oocytes. Mechanistically, LP exposure led to granulosa cell oxidative stress and mitochondria dysfunction via inhibiting SIRT3 activity and SOD2 deacetylation. Metabolomic analysis showed that LP exposure lowered NAD

interpretationOur study demonstrates that circadian rhythm disruption by LP exposure affect follicular development and ovulation through impaired NAD

fundingThis work was supported by the National Natural Science Foundation of China - Joint Fund for Regional Innovation and Development, the National Natural Science Foundation of China, the National Key Research and Development Program of China.

Indexed as

Circadian RhythmNADOvarian FollicleAnimalsCytokinesFemaleGranulosa CellsMetabolomicsMitochondriaNicotinamide PhosphoribosyltransferaseOvulationOxidative StressPhotoperiodRatsCytokinesNADNicotinamide PhosphoribosyltransferaseCircadian rhythmFollicular developmentGranulosa cellNAD(+)

Identifiers

PMID41797048
PMCPMC12991957

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.