Evidence map›Paper›PMID 41797044›Full record

ArticleRedox biology2026

TRPV1 and TRPA1 channels exhibit bifurcated sensing of singlet oxygen and hydrogen peroxide.

Yunshen Chen, Gaogao He, Wei Zhang, Jiajie Li, Xiaoxi Li, Sijun Dong, Qinglian Liu, Lei Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunshen ChenInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, PR China.
Gaogao HeSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100054, PR China.
Wei ZhangCollege of Life Sciences, Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, PR China.
Jiajie LiInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, PR China.
Xiaoxi LiInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, PR China.
Sijun DongCollege of Life Sciences, Hebei Basic Science Center for Biotic Interaction, Hebei University, Baoding, 071002, PR China.
Qinglian LiuDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Lei ZhouInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, PR China. Electronic address: zhoulei@szbl.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By responding to stimuli of diverse physics and chemical nature, transient receptor potential (TRP) channels fulfill important physiological functions in both excitable and non-excitable cells. Capsaicin (CAP) from chili peppers and allyl isothiocyanate (AITC) from mustard are natural and potent agonists for TRPV1 and TRPA1, respectively. Upon exposure to hydrogen peroxide (H

Indexed as

Hydrogen PeroxideSinglet OxygenTRPA1 Cation ChannelTRPV Cation ChannelsAnimalsCalciumCapsaicinHEK293 CellsHumansMembrane PotentialsReactive Oxygen SpeciesCalciumCapsaicinHydrogen PeroxideReactive Oxygen SpeciesSinglet OxygenTRPA1 Cation ChannelTRPA1 protein, humanTRPV1 protein, humanTRPV Cation ChannelsCalcium imagingHydrogen peroxideReactive oxygen speciesSinglet oxygenTRP channel

Identifiers

PMID41797044
PMCPMC12992509

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.