Evidence map›Paper›PMID 41796987›Full record

Trial reportJournal of clinical hypertension (Greenwich, Conn.)2026

Metformin Alters Exercise Training Induced Blood Pressure and Aortic Waveform Adaptations in Adults at Risk for Metabolic Syndrome.

Steven K Malin, Emily M Heiston, Daniel J Battillo, Tristan J Ragland, Ankit M Shah, James T Patrie

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Steven K MalinDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0002-7360-6711
Emily M HeistonDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.
Daniel J BattilloDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.
Tristan J RaglandDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.
Ankit M ShahDepartment of Medicine, Rutgers University, New Brunswick, New Jersey, USA.
James T PatrieDepartment of Public Health Science, Division of Biostatistics, University of Virginia, Charlottesville, Virginia, USA.

Funding

NIH HHS RO1-HL130296
6 · The paper itself

Abstract

Metformin reduces hyperglycemia and cardiovascular disease risk. However, no study has determined if metformin alters blood pressure and/or aortic waveforms in an exercise intensity dependent manner. We tested if metformin alters blood pressure and aortic waveforms before and during insulin-stimulation following low and high intensity exercise training. In a double-blind, placebo controlled trial, participants were randomized to low intensity exercise plus placebo (∼55% VO

Indexed as

AortaBlood PressureExerciseMetabolic SyndromeMetforminAdaptation, PhysiologicalAdultCarotid-Femoral Pulse Wave VelocityDouble-Blind MethodFemaleGlucose Clamp TechniqueHumansHypoglycemic AgentsInsulinMaleMiddle AgedHypoglycemic AgentsInsulinMetforminarterial stiffnessphysical activitypulse pressurereflection magnitudetype 2 diabetes

Identifiers

PMID41796987
PMCPMC12968050

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.