Evidence map›Paper›PMID 41796852›Full record

ArticleThe Journal of investigative dermatology2026

Optical and acoustic scattering in cutaneous neurofibromas: Implications for early detection.

Wangcun Jia, Nitesh Katta, Gordon T Kennedy, Junsoo Lee, Emily Nguyen, Oswald Lai, Yurie Jeong, Rachel Elsanadi, Feben Messele, James E Johnson and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wangcun JiaBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Nitesh KattaBeckman Laser Institute, University of California, Irvine, Irvine, California, USA; Michael E. DeBakey Center for Nano-Biophotonics, Baylor College of Medicine, Houston, Texas, USA.
Gordon T KennedyBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Junsoo LeeBeckman Laser Institute, University of California, Irvine, Irvine, California, USA; Michael E. DeBakey Center for Nano-Biophotonics, Baylor College of Medicine, Houston, Texas, USA.
Emily NguyenBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Oswald LaiBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Yurie JeongBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Rachel ElsanadiDepartment of Dermatology, University of California, Irvine, Irvine, California, USA.
Feben MesseleDepartment of Dermatology, University of California, Irvine, Irvine, California, USA.
James E JohnsonMichael E. DeBakey Center for Nano-Biophotonics, Baylor College of Medicine, Houston, Texas, USA.
Anat O Stemmer-RachamimovDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
J Stuart NelsonBeckman Laser Institute, University of California, Irvine, Irvine, California, USA.
Rafael SierraMedical Laser Consultant, Gulf Port, Florida, USA.
Kristen M KellyBeckman Laser Institute, University of California, Irvine, Irvine, California, USA; Department of Dermatology, University of California, Irvine, Irvine, California, USA.
Anthony J DurkinBeckman Laser Institute, University of California, Irvine, Irvine, California, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.
Thomas E MilnerMichael E. DeBakey Center for Nano-Biophotonics, Baylor College of Medicine, Houston, Texas, USA. Electronic address: Thomas.Milner@bcm.edu.

Funding

Spatial Frequency Domain Imaging for Burn Wound Severity AssessmentR01GM108634 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2014 to 2023
$2.8M
NIGMS NIH HHS R01 GM108634
6 · The paper itself

Abstract

Cutaneous neurofibromas (cNFs) occur in individuals with germline neurofibromatosis type I pathogenic variants. Current management involves monitoring and limited surgical removal. Nascent cNFs are lesions detectable only through advanced imaging and not observable with the unaided eye. Noninvasive early detection may enable intervention before cNF become visible. We introduce an imaging approach integrating spatial frequency domain imaging and high-frequency ultrasound to identify and characterize suspected nascent cNFs. In 21 participants with neurofibromatosis type I, we identified 152 suspected nascent lesions using spatial frequency domain imaging as skin regions with decreased optical scattering at near-infrared wavelengths. Of these, 120 were imaged with high-frequency ultrasound, and 93% demonstrated subsurface hypoechoic dermal structures. Paired analyses of the reduced scattering coefficient (μ

Indexed as

NeurofibromaNeurofibromatosis 1Skin NeoplasmsAdolescentAdultChildEarly DiagnosisFemaleHumansMaleScattering, RadiationSkinUltrasonographyYoung AdultCutaneous neurofibromasHigh-frequency ultrasoundSpatial frequency domain imaging

Identifiers

PMID41796852
PMCPMC13690417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.