Sleep disorders in children with Smith-Magenis Syndrome - a neurodevelopmental disorder with sleep-wake-rhythm-dysfunction - recommendations for pediatricians.

Alfred Wiater, Ann C M Smith, Wiebe Braam, Astrid Diederichs

Abstract readReview

In one paragraph

Review in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alfred WiaterPediatrician and sleep medicine specialist, Online consultant for pediatric sleep medicine, Grosse Neugasse 6, Cologne, Köln, 50667, Germany. praxis-wiater@t-online.de.ORCID 0009-0001-0289-2896

Ann C M SmithOffice of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Wiebe BraamGovernor Kremers Centre, Maastricht University, Maastricht, the Netherlands.

Astrid DiederichsSirius e.V. Advisory Board for medical treatment and research for individuals and families affected by SMS, Berlin, Germany.

Funding

NHGRI NIH HHS National Human Genome Research Institute

6 · The paper itself

Abstract

backgroundSleep disorders in children with Smith-Magenis Syndrome (SMS) are common. They affect not only the child but also the entire family. Disturbed sleep in SMS is caused by a sleep-wake rhythm dysfunction. SMS patients mostly have an inverted melatonin secretion rhythm with a peak in melatonin levels during the day. Therefore, children with SMS are often awake at night and sleepy during the day, followed by extremely severe behavioral problems. There are many recent scientific studies with treatment recommendations. PURPOSE: Since SMS is a rare disorder, many doctors are not familiar with it and parents of children with SMS are often left alone without medical support. The aim of this article is to summarize and explain the current state of knowledge about diagnostic and therapeutic pathways for sleep disorders in children with SMS. For parental counseling, there is an appendix with recommendations that physicians can use to provide parents with specific advice.

conclusionThis may lead to opportunities to develop personalized behavioral and treatment concepts.

Indexed as

Sleep Wake DisordersSmith-Magenis SyndromeChildHumansMelatoninMelatoninBehavioral therapyBetablockersCYP1A2MelatoninSleep disordersSmith Magenis Syndrome

Identifiers

PMID41796416

DOI10.1007/s11325-026-03640-z

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.