ArticleJournal of nanobiotechnology2026
Microneedle-based delivery of cell membrane vesicles as IL-17RA decoys for Psoriasis treatment.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immune cell-derived membrane nanovesicles: A promethean fire for autoimmune disease therapy through immune cell mimicry.Bioactive materials · 2026Review
- Can Microneedle-Nanocarrier Platforms Deliver True Tolerogenic Immunotherapy for Psoriasis?Vaccines · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The dysregulation of IL-17/IL-17 receptor A (IL-17RA) signaling axis is a central driver of multiple autoimmune diseases. In contrast to targeting individual IL-17 cytokines, blocking IL-17RA simultaneously inhibits the receptor engagement of multiple IL-17 ligands, thereby effectively suppressing downstream pathway activation. Brodalumab, the only approved IL-17RA-blocking antibody, suggests robust clinical efficacy. However, its inhibition of IL-17RA has been associated with an increase in systemic IL-17 C levels, which is related to suicidal ideation and behavior. Consequently, the development of novel strategies capable of broadly blocking IL-17 signaling remains critically important. This study developed a novel therapeutic strategy by engineering cell-membrane vesicles with IL-17RA (IL-17RA-CMVs) as high-avidity decoy receptors for effectively blocking the IL-17/IL-17 receptor A (IL-17RA) signaling axis. Stable 293T cell lines exhibiting high surface expression of mouse or human IL-17RA (m/hIL-17RA), mediated by a platelet-derived growth factor receptor (PDGFR) transmembrane domain, were successfully constructed and applied for the preparation of m/hIL-17RA-CMVs. The mIL-17RA-CMVs were efficiently loaded into hyaluronic acid-based microneedles (mIL-17RA-CMVs-MNs), and the resulting mIL-17RA-CMVs-MNs exhibited sufficient mechanical strength to penetrate the skin and rapidly dissolved within 5 min upon insertion. In an imiquimod (IMQ)-induced murine psoriasis model, the topical application of mIL-17RA-CMVs-MNs significantly alleviated disease severity, as evidenced by a remarkable reduction in Psoriasis Area and Severity Index (PASI) scores, suppression of epidermal hyperplasia, and normalization of spleen index. Mechanistic studies revealed that the treatment mIL-17RA-CMVs-MNs markedly downregulated the expression of key IL-17RA pathway-related inflammatory mediators (CXCL1, CXCL2, CCL20) and antimicrobial peptides (S100A7/A8/A9) in skin lesions. Furthermore, in vitro experiments indicated that hIL-17RA-CMVs effectively functioned as decoy receptors, neutralizing IL-17 A and consequently inhibiting the upregulation of pro-inflammatory cytokines and hyperproliferation in HaCaT keratinocytes. This study presents a pioneering approach that synergizes the broad-spectrum neutralization capability of engineered decoy receptor vesicles with the localized and minimally invasive delivery advantage of microneedles. These findings position IL-17RA-CMVs (or IL-17RA-CMVs-MNs) as a highly promising and translatable therapeutic modality for the treatment of psoriasis and potentially other IL-17-mediated inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.