Evidence map›Paper›PMID 41796353›Full record

ArticleJournal of nanobiotechnology2026

Photothermal reprogramming of synovial M1 macrophages reshapes the pro-inflammatory microenvironment to reverse temporomandibular joint osteoarthritis.

Yanyi Wang, Jiangyan Ren, Tingyu Ren, Baochao Li, Jianchuan Ran, Huijuan Wang, Ziwei Huang, Diya Xie, Tao Liu, Linzhong Yang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yanyi WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Jiangyan RenNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Tingyu RenNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Baochao LiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Jianchuan RanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Huijuan WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Ziwei HuangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Diya XieNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Tao LiuShanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200001, China.
Linzhong YangDepartment of Oral and Maxillofacial Surgery, Nantong Stomatological Hospital, Nantong, 226001, China.
Jinglun ZhangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Caixia ZhangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Zhi WangNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Xingyu LuoNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China.
Lei ZhengFaculty of Dentistry, National University of Singapore, Singapore, 119083, Singapore.
Xiaoji XieState Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, 211816, China.
Huang LiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China. lihuang76@nju.edu.cn.
Wei HanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Research Institute of Stomatology, Nanjing University, Nanjing, 210008, China. doctorhanwei@nju.edu.cn.

Funding

"2015" Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School, Medical School of Nanjing University 0223A101the High-Level Hospital Construction Project of Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University 0224C005the High-Level Hospital Construction Project of Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University KY-2025NL-101the Key Project of the Health Commission of Jiangsu Province ZD2022025the Nanjing Health Science and Technology Development Project YKK23186the National Natural Science Foundation of China 82473178
6 · The paper itself

Abstract

Temporomandibular joint osteoarthritis (TMJOA) involves progressive synovial inflammation-driven cartilage degeneration. While thermotherapy empirically alleviates symptoms, its immunomodulatory mechanism remains elucidated. Here, we revealed that targeted mild hyperthermia reprogramed synovial M1 macrophages via NF-κB pathway suppression, shifting their secretome to attenuate chondrocyte catabolism while enhancing anabolism. This thermally-modified macrophage conditioned medium concurrently promoted osteogenic mineralization. Capitalizing on this, we engineered folic acid-conjugated Y8 nanocomposites (FA-Y8 NPs) for precision M1-targeting photothermal therapy. Under 808 nm irradiation, FA-Y8 NPs achieved localized photothermal reprogramming of synovial M1 macrophages and attenuating cartilage degradation in CFA-induced TMJOA mice. This study reveals thermal immunomodulation of synovial macrophages as a potential mechanism for TMJOA remission and establishes a targeted nanoplatform for spatial control of joint inflammation.

Indexed as

MacrophagesOsteoarthritisPhotothermal TherapyAnimalsInflammationMaleMiceMice, Inbred C57BLNanocompositesNF-kappa BSynovial MembraneTemporomandibular JointNF-kappa BNanoparticlesPhotothermal therapyPro-inflammatory microenvironmentSynovial macrophagesTemporomandibular joint osteoarthritis

Identifiers

PMID41796353
PMCPMC13081524

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.