Evidence map›Paper›PMID 41796272›Full record

ArticleThe international journal of cardiovascular imaging2026

Impact of peak strain dispersion and septal flash on left ventricular myocardial work in patients with complete left bundle branch block.

Jie Xiao, Wanqing Hou, Shengnan Lin, Hongda Su, Runzi Ling, Yongqi Zheng, Xiaojian Ye, Lei Yan

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Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jie Xiao *Department of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Wanqing Hou *Department of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Shengnan Lin *Department of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Hongda SuDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Runzi LingDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yongqi ZhengDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Xiaojian YeDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Lei YanDepartment of Ultrasound, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. yanlei20082336@163.com.

Funding

Leading Project Foundation of Science and Technology, Fujian Province No.2022Y0010Provincial subsidy fund for health and wellness from Fujian Provincial Department of Finance No.BPB-2022YXJ
6 · The paper itself

Abstract

This study used two‑dimensional speckle‑tracking imaging (2D‑STI) and pressure‑strain loop (PSL) analysis to investigate the impact of peak strain dispersion (PSD) and septal flash (SF) on left ventricular myocardial work in patients with complete left bundle branch block (CLBBB). We enrolled 110 patients with CLBBB, stratified by the presence (n = 69) or absence (n = 41) of SF, and 45 matched controls. Two-dimensional speckle tracking imaging was employed to obtain the PSD (defined as the standard deviation of the time to peak longitudinal strain in all left ventricular segments). PSL analysis quantified global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE), global work index (GWI) and regional myocardial work parameters. The correlations of SF and PSD with work indices were assessed, and multivariate regression identified predictors of left ventricular systolic dysfunction (GWI < 1907 mmHg%). The SF group exhibited significantly higher PSD and GWW, and lower GWE, GWI, and GCW than the non-SF group (all p < 0.05). Both SF and higher PSD were negatively correlated with the work indices of the septum, free wall, and their ratios (all p < 0.01). Multivariate analysis confirmed that SF (OR: 2.717, 95% CI: 1.037-7.119) and PSD (OR: 1.055, 95% CI: 1.019-1.093) are independent risk factors for left ventricular systolic dysfunction. CLBBB patients with SF have greater left ventricular systolic impairment, coupled with septal-to-free wall workload imbalance. PSD, a global dyssynchrony parameter, complements the local visual index SF.

Indexed as

Bundle-Branch BlockEchocardiography, DopplerGlobal Longitudinal StrainMyocardial ContractionVentricular Dysfunction, LeftAgedBiomechanical PhenomenaCase-Control StudiesFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRisk FactorsVentricular Function, LeftComplete left bundle branch blockMyocardial workPeak strain dispersionSeptal flashSystolic function

Identifiers

PMID41796272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.