ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Quality of life and burden in family caregivers of advanced cancer patients in the Grand Duchy of Luxembourg: results from a single-centre study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
purposeThe diagnosis of advanced tumour disease significantly impacts patients' and their family caregivers' (FCs) life, affecting the physical, emotional, and social well-being. Our study aimed to assess the burden and quality of life (QoL) of FCs of advanced cancer patients in Luxembourg. Furthermore, the acceptance and feasibility of the used questionnaires were evaluated.
methodsA cross-sectional study was conducted over 6 months, including FCs of patients with advanced cancer receiving active treatment or best supportive care. The Short-Form Zarit Burden Interview (ZBI-12) and Short-Form Health Survey (SF-36) were used to assess FCs' burden and QoL. Sociodemographic and clinical data were collected through a self-completed questionnaire. The Pearson and Spearman correlations, t-tests, and ANOVA were performed.
resultsOne hundred FCs were invited of whom 88.0% agreed to participate, and 60.2% returned completed questionnaires. FCs reported impaired QoL across all SF-36 subscales, with health change and energy/fatigue being the most impaired. ZBI-12 scores showed a statistically significant negative correlation with SF-36 scores, particularly in health domains such as role limitations due to emotional problems and (overall) health change (Pearson's r = 0.650-0.640, p < 0.001). Higher caregiving burden was associated with significantly lower QoL, influenced by individual caregiver characteristics.
conclusionsThis is the first study in Luxembourg to assess burden and QoL of FCs of patients with advanced cancer. Findings demonstrate a strong association between increased caregiver burden and lower QoL. The questionnaire was highly accepted by the FCs. Regular assessments of caregiver burden and tailored support interventions by healthcare professionals are recommended.
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