Evidence map›Paper›PMID 41796205›Full record

ArticleScientific reports2026

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients.

Nikolaus Wick, M Hermann, Christoph Lisch, Regine Gerth, Georg Wick, Eva Untersmayr, Tatjana Marth, Mirjam Bachler, Dietmar Fries

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nikolaus WickSpecialized Laboratories Wick, Speckbacherstrasse 23, 6020, Innsbruck, Austria. nikolaus.wick@laborwick.com.ORCID http://orcid.org/0009-0003-5482-4486
M HermannDepartment of Anesthesia and Intensive Care, Medical University Innsbruck, Innsbruck, Austria.
Christoph LischOrdination Dr. Lisch, Hochrum, Austria.
Regine GerthSpecialized Laboratories Wick, Speckbacherstrasse 23, 6020, Innsbruck, Austria.
Georg WickDivision of Pathophysiology, Biocenter, Medical University Innsbruck, Innsbruck, Austria.
Eva UntersmayrCenter for Pathophysiology and Allergy Research, Medical University of Vienna, Wien, Austria.
Tatjana MarthFachhochschule Für Gesundheit, Innsbruck, Austria.
Mirjam BachlerDepartment of Anesthesia and Intensive Care, Medical University Innsbruck, Innsbruck, Austria.
Dietmar FriesDepartment of Anesthesia and Intensive Care, Medical University Innsbruck, Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome. Among many pathophysiological hypotheses we focus on impaired hemostasis as well as reactivation of latent Epstein-Barr virus. We now introduce a novel diagnostic morphological approach for visualizing microaggregates circulating in peripheral venous blood, which are large enough to impede capillary blood flow. In addition, secretion of interferon gamma by mononuclear leukocytes in response to peptides of Epstein-Barr virus is increased in these patients. As a promising therapeutic approach, we provide retrospective data on the effect of anti-thrombotic and virostatic drugs, respectively. In a large number of patients, clinical improvement was observed after platelet inhibition, particularly when EBV was also treated with antiviral therapy.

Indexed as

COVID-19Epstein-Barr Virus InfectionsHerpesvirus 4, HumanVirus ActivationAgedAntiviral AgentsFemaleHumansInterferon-gammaLeukocytes, MononuclearMaleMiddle AgedPlatelet Aggregation InhibitorsPost-Acute COVID-19 SyndromeRetrospective StudiesSARS-CoV-2Antiviral AgentsInterferon-gammaPlatelet Aggregation InhibitorsAnti-thromboticEpstein-Barr virusMicroclotsPost-CoVIDValaciclovir

Identifiers

PMID41796205
PMCPMC13086941

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.