Evidence map›Paper›PMID 41796140›Full record

ArticleScientific reports2026

Deciduous pulp stem cell-derived extracellular vesicles stimulate the proliferation of cartilage progenitor cells via extracellular signal-regulated protein kinase 1/2 activation.

Sara Murata, Soichiro Sonoda, Yukari Kyumoto-Nakamura, M Majd Sharifa, Liting Yu, Reona Aijima, Erika Yamauchi-Tomoda, Fouad Mhd Zakaria, Hiroki Kato, Norihisa Uehara and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara Murata *Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Soichiro Sonoda *Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Yukari Kyumoto-NakamuraDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
M Majd SharifaDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Liting YuDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Reona AijimaDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Saga University Graduate School of Dental Science, Fukuoka, Japan.
Erika Yamauchi-TomodaDepartment of Oral and Maxillofacial Radiology, Kyushu University Graduate School of Dental Science, Fukuoka, Japan.
Fouad Mhd ZakariaDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Hiroki KatoDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Norihisa UeharaDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Haruyoshi YamazaDepartment of Pediatric Dentistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 890-8544, Japan.
Takayoshi YamazaDepartment of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan. yamazata@dent.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0001-7055-3370

Funding

Japan Society for the Promotion of Science JP21J10881Japan Society for the Promotion of Science JP21K16932Japan Society for the Promotion of Science JP22K19565
6 · The paper itself

Abstract

The developmental dysfunction of cartilage progenitor cells (CPCs) causes dwarfism. Radical therapies for dwarfism remain underdeveloped. Recently, the therapeutic benefits of extracellular vesicles (EVs) released from human exfoliated deciduous tooth-derived stem cells (SHED) have been investigated for their potential to restore disease-target cells. However, the effects of EVs on human CPCs for the treatment of dwarfism remain unclear. We investigated the impact of EVs on cell proliferation, telomerase activity, telomerase reverse transcriptase (TERT) expression, cell cycle, and extracellular signal-regulated protein kinase 1/2 (ERK1/2) levels in human CPCs and in our established osteogenesis imperfecta (OI)-specific SHED (OI-SHED). EVs enhanced the proliferation and G1/S phase transition of CPCs, which was associated with increased TERT expression and telomerase activity. However, RNase-preconditioned EVs did not attenuate the efficacy of EVs in CPCs. ERK1/2 inhibitor tests demonstrated that CPCs exhibited suppressed proliferation, telomerase activity, and G1/S phase progression. EV-transferring CD29 induced ERK1/2 phosphorylation in CPCs, subsequently activating telomerase activity to induce proliferation. Interestingly, EV stimulation restored the reduction in cell proliferation, cell cycle progression, phosphorylated ERK1/2 levels, and TERT expression in OI-SHED. In conclusion, the present findings provide new insights into ERK1/2-mediated proliferation of human CPCs using EVs.

Indexed as

CartilageDental PulpExtracellular VesiclesMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Stem CellsTooth, DeciduousCell ProliferationCells, CulturedHumansTelomeraseMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3TelomeraseCartilage progenitor cellsExtracellular signal-regulated kinase 1 and 2Extracellular vesiclesG1/S phase transitionStem cells from human exfoliated deciduous teethTelomerase activity

Identifiers

PMID41796140
PMCPMC13087214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.