ArticleJournal of atherosclerosis and thrombosis2026
Prognostic Significance of the Estimated Small Dense Low-Density Lipoprotein Cholesterol Levels in Predicting the Incidence of Coronary Artery Disease: The Nagahama Study and Shizuoka Kokuho Database Study.
Article in Journal of atherosclerosis and thrombosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSmall dense low-density lipoprotein cholesterol (sdLDLC) has been suggested to be more harmful for cardiovascular outcomes than total LDLC. This study aimed to clarify the prognostic significance of the estimated sdLDLC for the incidence of coronary artery diseases (CAD).
methodsWe analyzed the clinical information obtained at an annual health checkup of 365,083 adults aged 40-74 years enrolled in the National Health Insurance system in Japan. The incidence of CAD was determined using the health insurance claims data. Additionally, we calculated Japanese-specific coefficients of the sdLDLC estimation equation using general population data, where the measured sdLDLC value was available (n = 9,558).
resultsThe estimated sdLDLC level calculated from the total LDLC and triglyceride levels was correlated with the measured sdLDLC level (coefficient of determination = 0.768) and it was significantly associated with the CAD incidence (hazard ratio per 10 mg/dL = 1.21, p＜0.001). Although the total LDLC showed a similar association, the estimated sdLDLC ≥ 30 mg/dL (hazard ratio = 1.97, p = 0.016) and ≥ 40 mg/dL (hazard ratio = 2.57, p = 0.001) were significantly associated with CAD, even in participants with normal LDLC levels (＜120 mg/dL). The cross-sectional association of the measured sdLDLC with the pulse wave velocity of the large artery (β = 0.034, p＜0.001) was significant, while that of the estimated sdLDLC (β = 0.014, p = 0.057) was not.
conclusionThe estimated sdLDLC may be a straightforward and cost-effective marker for identifying individuals with normal LDLC levels at risk of CAD. However, the measured sdLDLC may be a more favorable marker than the estimated sdLDLC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.