Evidence map›Paper›PMID 41795919›Full record

ArticleThe Journal of reproduction and development2026

Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.

Miki Muroi, Shiho Fukuda, Miki Takahashi, Tatsuya Suzuki, Masakatsu Fujinoki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Regulation of spermatozoal capacitation by serotonin.The Journal of reproduction and development · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miki MuroiReproductive Medicine Center, Dokkyo Medical University Hospital, Tochigi 321-0293, Japan.
Shiho FukudaDepartment of Obstetrics and Gynecology, Dokkyo Medical University, Tochigi 321-0293, Japan.
Miki TakahashiReproductive Medicine Center, Dokkyo Medical University Hospital, Tochigi 321-0293, Japan.
Tatsuya SuzukiReproductive Medicine Center, Dokkyo Medical University Hospital, Tochigi 321-0293, Japan.
Masakatsu FujinokiLaboratory for Reproductive Medicine, Research Center for Advanced Medical Science, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study in hamsters indicated that progesterone (P) induces enhancement of spermatozoal hyperactivation, while 17β-estradiol (Eβ) and γ-aminobutyric acid (GABA) suppress this enhancement. Since P has also been shown to enhance hyperactivation of rat spermatozoa in another study conducted by our team, we examined the effects of Eβ and GABA on the P-enhanced hyperactivation of rat spermatozoa in the present study. Our results showed that Eβ suppressed P-enhanced hyperactivation in a dose-dependent manner through an estrogen receptor. In contrast, GABA did not affect P-enhanced hyperactivation. Instead, 5-500 fM GABA significantly enhanced spermatozoal hyperactivation, and this GABA-induced enhancement of hyperactivation was associated with a GABA

Indexed as

Estradiolgamma-Aminobutyric AcidProgesteroneSpermatozoaSperm CapacitationSperm MotilityAnimalsMaleRatsReceptors, GABA-AEstradiolgamma-Aminobutyric AcidProgesteroneReceptors, GABA-A17β-estradiolhyperactivationprogesteronespermatozoaγ-aminobutyric acid

Identifiers

PMID41795919
PMCPMC13441482

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.