ReviewDiscover oncology2026
The combination therapy with venetoclax in therapeutic strategy of acute lymphoblastic leukemia.
Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute lymphoblastic leukemia (ALL) is characterized by the malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. Leukemic cells can develop drug resistance both before and after treatment, complicating disease management. Combination therapy with Venetoclax has been shown to enhance the efficacy of standard anti-leukemia drugs. Therefore, this study aims to review combination treatment strategies as potential therapeutic alternatives, drawing on evidence from previous published literature.
methodsThis narrative review summarizes and critically discusses published preclinical and clinical studies evaluating Venetoclax-based combination therapies in ALL, with an emphasis on mechanistic rationale and therapeutic implications.
resultsAvailable evidence indicates that combinations of Venetoclax with hypomethylating agents, monoclonal antibodies, kinase inhibitors, and cytotoxic chemotherapies may enhance apoptotic signaling and improve antileukemic activity across multiple ALL subtypes, including high-risk and heavily pretreated populations.
conclusionVenetoclax-based combination strategies represent a promising and flexible therapeutic approach in ALL. However, current evidence is largely derived from heterogeneous and non-randomized studies, underscoring the need for well-designed prospective trials to define optimal regimens and patient selection.
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