ArticleDiscover oncology2026
Association of lncRNA AGAP11 with prognosis and malignant progression in triple-negative breast cancer.
Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTriple-negative breast cancer (TNBC) is aggressive with poor prognosis and limited reliable prognostic markers.
objectivesThis study investigated the association between long non-coding RNA (lncRNA) ArfGAP With GTPase Domain, Ankyrin Repeat and PH Domain 11 (AGAP11) expression and clinicopathological characteristics and prognosis of early-stage TNBC patients, along with experimental validation of the regulatory effect of AGAP11 on TNBC cell malignancy and the tumor microenvironment through targeting miR-1269a.
methodsThis retrospective study examined 126 early-stage TNBC patients. AGAP11 and miR-1269a expression levels were detected using quantitative polymerase chain reaction (qPCR). The clinical significance of AGAP11 was analyzed. The impact of AGAP11 overexpression alone and in conjunction with miR-1269a overexpression, on the behavior of TNBC cells and the tumor microenvironment was examined.
resultsAGAP11 was down-regulated in TNBC tissues and cells (P < 0.001). Low AGAP11 expression was significantly associated with adverse clinicopathological characteristics (P < 0.05). Low AGAP11 was an independent risk factor for poor prognosis (HR = 0.254, P = 0.006) and predicted worse 5-year survival (P = 0.003). AGAP11 overexpression inhibited TNBC cell malignant activity (P < 0.05), and disrupted the homeostasis of the tumor microenvironment (P < 0.05). MiR-1269a was up-regulated in TNBC (P < 0.001). AGAP11 directly binds miR-1269a, and miR-1269a co-overexpression reversed inhibitory effects by AGAP11 (P < 0.05).
conclusionAGAP11 is a potential prognostic biomarker for TNBC and an important parameter for clinical stratification. Through the AGAP11/miR-1269a axis, it regulates TNBC cell behavior and the tumor microenvironment, which offers new insights for precision diagnosis and treatment.
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