Evidence map›Paper›PMID 41795700›Full record

ArticleJournal of periodontal research2026

Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin.

Larysa Saboya Cavalotti Perdonsini, Rafael Scaf de Molon, Søren Jepsen, Iain Chapple, Joao Paulo Steffens

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Larysa Saboya Cavalotti PerdonsiniPostgraduate Program in Dentistry, Universidade Federal Do Paraná, Curitiba, Paraná, Brazil.
Rafael Scaf de MolonSchool of Dentistry at Araçatuba, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1110-6233
Søren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
Iain ChappleSchool of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0003-2697-7082
Joao Paulo SteffensPostgraduate Program in Dentistry, Universidade Federal Do Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-6071-553X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non-communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or immunomodulatory activity.

Indexed as

ExerciseFibronectinsPeriodontitisBiomarkersHumansMyokinesSalivaBiomarkersFibronectinsFNDC5 protein, humanMyokinescytokinesmyokinesnon‐communicable diseasesperiodontitis

Identifiers

PMID41795700
PMCPMC13472005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.