Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial.
Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02669394 (Reshaping the Path of Vascular Cognitive Impairment With Resistance Training), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reshaping the Path of Vascular Cognitive Impairment With Resistance Training
Who cites it
2 citing papers in PubMed.
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Exercise-induced anti-inflammatory adaptation in older adults: a Bayesian network meta-analysis and dose-response analysis of C-reactive protein.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
introductionIt is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]).
methodsWe conducted a 12-month randomized trial comparing PRT versus balance and tone exercises (BAT) on the Alzheimer's Disease Assessment Scale Cognitive Plus (ADAS-Cog-Plus).
resultsNinety-one participants were randomized (PRT = 45; BAT = 46); 76 completed the trial. Adherence was not different between groups (p = 0.18). At 12 months, PRT significantly improved ADAS-Cog-Plus scores (estimated mean difference: -0.18; 95% confidence interval [CI: -0.35, -0.01]; p = 0.04). Planned contrasts stratified by sex showed a significant PRT effect on ADAS-Cog-Plus scores for females (mean difference: -0.27; 95% CI: [-0.49, -0.05]; p = 0.02), but not for males. PRT also significantly reduced C-reactive protein (estimated mean difference: -2.93; 95% CI: [-5.36, -0.49]; p = 0.02). No significant differences were observed for other secondary outcomes. DISCUSSION: PRT may have a small beneficial effect on cognitive function in SVCI. CLINICAL
trial registrationThis trial was registered with ClinicalTrials.gov (NCT02669394).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.