Evidence map›Paper›PMID 41795679›Full record

ArticleThe New phytologist2026

AGP and EXO-LIKE genes promote brassinosteroid-dependent anisotropic growth.

Daria Novikova, Surbhi Rana, Kunkun Li, H Nicholay Diaz-Ardila, Nicola Trozzi, Luis Alonso Baez, Thorsten Hamann, Mateusz Majda, Christian S Hardtke

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Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Daria NovikovaDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.
Surbhi RanaDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0002-3894-6307
Kunkun LiDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0003-1597-197X
H Nicholay Diaz-ArdilaDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0001-7212-8343
Nicola TrozziDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.
Luis Alonso BaezInstitute for Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491, Norway.ORCID https://orcid.org/0000-0002-6834-6046
Thorsten HamannInstitute for Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, 7491, Norway.
Mateusz MajdaDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0003-3405-2901
Christian S HardtkeDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0003-3203-1058

Funding

H2020 European Research Council 101118769-HYDROSENSINGSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_207876
6 · The paper itself

Abstract

The brassinosteroid pathway promotes anisotropic cell expansion; however, the effectors in this process remain unclear. Candidates include ARABINOGALACTAN PROTEIN (AGP) genes, which are prominent brassinosteroid-responsive transcriptional targets, and EXORDIUM (EXO)-LIKE (EXL) genes. Here, we examined whether AGP and EXO/EXL genes mediate anisotropic cell expansion. AGPs are evolutionarily ancient glycoproteins, which are secreted and attached to the plasma membrane. Plant genomes contain dozens of potentially redundant AGP genes. Their roles have mostly been inferred from the phenotypes of beta-glycosyltransferase mutants with impaired AGP glycosylation. Compared with AGPs, little is known about the smaller family of secreted EXO/EXL proteins. Here, we investigated brassinosteroid-dependent AGP and EXO/EXL gene expression patterns in Arabidopsis roots and created loss-of-function mutants for preponderant genes. Whereas single, double and triple agp mutants appeared wild-type, combinatorial quadruple to sextuple agp2/4/10/11/13/22/24 mutants displayed longer, frequently aberrant root hairs and shorter yet thicker roots. These traits reflect an underlying reduced cellular anisotropy associated with increased organ stiffness, which were also observed in hypocotyls. Combinatorial exo/exl1/2/3/4/5/6/7 sextuple or septuple mutants displayed a qualitatively similar but quantitatively weaker phenotype than combinatorial agp mutants. Collectively, our data suggest that classical/peptide AGPs and EXO/EXLs promote brassinosteroid-dependent anisotropic growth to different extent.

Indexed as

ArabidopsisArabidopsis ProteinsBrassinosteroidsGenes, PlantMucoproteinsAnisotropyGene Expression Regulation, PlantMutationPhenotypePlant ProteinsPlant RootsArabidopsis Proteinsarabinogalactan proteinsBrassinosteroidsMucoproteinsPlant Proteinsarabinogalactan peptidesarabinogalactan proteinscellular anisotropyEXORDIUMorgan stiffnessroot

Identifiers

PMID41795679
PMCPMC13103426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.