Evidence map›Paper›PMID 41795672›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Alzheimer's disease and related dementias among transfeminine adults: A cohort study.

Ethan C Cicero, Jace D Flatt, Oumaima Kaabi, Vin Tangpricha, Darios Getahun, Courtney McCracken, Timothy L Lash, Michael J Silverberg, Suma Vupputuri, Molly Perkins and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ethan C CiceroNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA.
Jace D FlattSchool of Public Health, Department of Social and Behavioral Health, University of Nevada, Las Vegas, Nevada, USA.
Oumaima KaabiRollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Vin TangprichaDivision of Endocrinology, Metabolism & Lipids, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Darios GetahunDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Courtney McCrackenCenter for Research and Evaluation, Kaiser Permanente Georgia, 9 Piedmont Center, Atlanta, Georgia, USA.
Timothy L LashRollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Michael J SilverbergDivision of Research, Kaiser Permanente, Northern California, Pleasanton, California, USA.
Suma VupputuriMid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Washington, District of Columbia, USA.
Molly PerkinsDivision of Geriatrics and Gerontology, Department of Medicine, Emory University, Atlanta, Georgia, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Michael GoodmanRollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Funding

An intersectional approach linking Minority Stressors Experienced by Transgender and Gender Diverse Adults to Alcohol and Drug Use and comorbid Mental and Physical Health OutcomesR01AA030275 · NIAAA · GEORGIA STATE UNIVERSITY · PI SALAZAR, LAURA F · 2023 to 2024
$992k
The Brain Health of Transgender and Gender Diverse Adults: An Examination of Alzheimer’s Disease and Related Dementias Risk and Psychosocial StressorsK23AG084851 · NIA · EMORY UNIVERSITY · PI Ethan Collin Cicero · 2024 to 2026
$589k
Alzheimer's Association 23AARGD-NTF-1028973NIAAA NIH HHS R01AA030275NIA NIH HHS K23 AG084851NIA NIH HHS K23AG084851
6 · The paper itself

Abstract

introductionWe investigated whether Alzheimer's disease and related dementias (ADRD) are more common among transfeminine (TF) adults than among demographically similar cisgender people enrolled in the same health system.

methodsWe analyzed electronic health records of 856 TF adults aged 65+ and matched cisgender men (CM) and cisgender women (CW) and compared ADRD prevalence across groups by calculating enrollment-adjusted odds ratios (aOR) and 95% confidence intervals (CI).

resultsThe aOR of ADRD among TF adults were 1.39 (95% CI: 0.99-1.97) relative to CM and 1.29 (95% CI: 0.92-1.82) relative to CW referents. For TF adults with evidence of receiving gender-affirming hormone therapy (GAHT) receipt, the associations were slightly stronger: 1.75 (1.13-2.69) and 1.70 (1.11-2.60). Results restricted to minoritized ethnoracial groups appeared smaller, but imprecise. DISCUSSION: These findings suggest that ADRD diagnosis and management may represent a priority in the healthcare of older TF people, particularly those with a history of GAHT.

Indexed as

Alzheimer DiseaseDementiaTransgender PersonsAgedAged, 80 and overCohort StudiesFemaleHumansMalePrevalenceAlzheimer's diseaseelectronic health recordsgender minorityprevalencetransfemininetransgender

Identifiers

PMID41795672
PMCPMC12967476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.