ArticleMedical physics2026
A Monte Carlo study of proton LET calculations: Comparison between the codes PENHAN, FLUKA, and TOPAS.
Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundLinear energy transfer (LET) is frequently used to characterize radiation quality in proton therapy and is an important quantity for radiobiological modeling. However, LET calculations can, in principle, vary between Monte Carlo (MC) codes, affecting consistency in treatment planning and relative biological effectiveness (RBE) estimation. PURPOSE: This study aims to investigate the variability of LET results when using different MC codes.
methodsAn intercomparison of LET results was performed using penhan, topas MC, and CERN fluka, together with recently published experimental data. Track-averaged (
resultsThe results obtained indicate that discrepancies in LET calculations are primarily linked to the choice of stopping powers and the handling of nuclear interactions. Calculations considering only primary protons exhibited great agreement with recent experimental LET measurements, validating our simulations.
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