ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Interpreting "intermittent" psychological distress in dementia research: A classification that obscures more than it reveals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The association between digital literacy and cognitive function in older adults: the multiple mediating roles of self-efficacy, social participation, and psychological resilience.Frontiers in aging · 2026Article
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12 authors.
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Abstract
introductionPsychological distress has been linked with cognitive impairment. However, whether the relationship is causal, reflects preclinical dementia neuropathology, or confounding by common causes remains unclear.
methodsIn five UK longitudinal studies, we examined associations of psychological distress with subsequent cognition using linear and mixed effects models, and dementia using logistic regression. We examined variation by age-at-assessment, severity, and distress persistence, combining study-specific estimates using two-stage individual participant data meta-analysis.
resultsPooling across studies (N = 24,564), greater baseline psychological distress was associated with lower subsequent cognitive level (β = -0.03 [95% confidence interval [CI]: -0.06; -0.01]; I DISCUSSION: Findings highlight the relevance of psychological distress in later cognitive outcomes, with potential future implications for dementia prevention and identifying high-risk groups.
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