Evidence map›Paper›PMID 41795661›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Dual association patterns between microglial activation and neuronal health in Alzheimer's disease: a whole-brain MRSI/PET study.

Yaoyu Zhang, Xiao-Hang Qian, Huixiang Zhuang, Wenqi Zhang, Jialin Hu, Yibo Zhao, Yudu Li, Wen Jin, Chang Xu, Ziyu Meng and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yaoyu ZhangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-6619-0762
Xiao-Hang QianDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huixiang ZhuangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wenqi ZhangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jialin HuDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yibo ZhaoBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Yudu LiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Wen JinBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Chang XuDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Ziyu MengDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wenli LiDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Siyue ChenDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu-Feng JiangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Tengfei GuoInstitute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, China.
Ya-Dong LiDepartment of Gastroenterology, Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jian YeDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zhi-Pei LiangBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Miao ZhangDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Huidong TangDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao LiDepartment of Nuclear Medicine, Ruijin Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-5009-7443

Funding

Guangci Clinical Technology and Innovation Program (GCTIP) of Ruijin Hospital GCQH2023061Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2023QNA46Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2023ZD22Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2025QNA45Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University YG2025ZD31National Natural Science Foundation of China 82372073National Natural Science Foundation of China 82501770National Natural Science Foundation of China 82571772Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher LearningShanghai Key Laboratory of Child Brain and Development 24dz2260100Shanghai Municipal Health Commission 202240031Shanghai Pilot Program for Basic Research - Shanghai Jiao Tong University 21TQ1400203
6 · The paper itself

Abstract

introductionMicroglial activation can either support neuronal function or exacerbate damage, contributing to Alzheimer's disease (AD) progression. We investigated spatial relationships among microglial activation, neuronal health, and amyloid beta (Aβ) in the AD spectrum.

methodsForty healthy controls, 37 patients with mild cognitive impairment (MCI), and 62 patients with AD underwent whole-brain high-resolution

resultsMCI and AD patients showed higher microglial activation and lower NAA, correlating with cognitive decline. In controls and MCI, microglial activation correlated positively with NAA and Aβ in early amyloid-accumulating regions. Conversely, negative correlations with NAA emerged in the hippocampus in MCI and extended to temporal and occipital regions in AD. DISCUSSION: For the first time, we identified two distinct spatial association patterns between [

Indexed as

Alzheimer DiseaseBrainCognitive DysfunctionMicrogliaNeuronsPositron-Emission TomographyAgedAmyloid beta-PeptidesAspartic AcidFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedAmyloid beta-PeptidesAspartic AcidN-acetylaspartateAlzheimer's diseaseamyloid betamagnetic resonance spectroscopic imagingmicroglial activationN‐acetylaspartateneuroinflammation

Identifiers

PMID41795661
PMCPMC12967485

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.