Evidence map›Paper›PMID 41795628›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026

A Novel Slit Lamp-Based System for 3D Ultrasound of the Eye.

Claire E Malley, Joseph P Miller, Boyan Pan, Josiah K To, Jack O Thomas, Steven Y Chang, Jason Dagoon, William C Tang, Parsa Riazi Esfahani, Andrew W Browne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Claire E MalleyGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.
Joseph P MillerGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.
Boyan PanGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.
Josiah K ToGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-2747-0582
Jack O ThomasGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.
Steven Y ChangGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-7124-8324
Jason DagoonGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.
William C TangDepartment of Biomedical Engineering, Henry Samueli School of Engineering, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-4183-520X
Parsa Riazi EsfahaniGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-4874-6886
Andrew W BrowneGavin Herbert Eye Institute - Center for Translational Vision Research, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0001-5351-461X

Funding

In vivo 2-photon imaging of retinal biochemistry before and after retinal organoid transplantationK08EY034912 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BROWNE, ANDREW W · 2023 to 2025
$583k
Arnold and Mabel Beckman FoundationBrightFocus Foundation M2021013NNational Institutes of Health (NIH) K08 Career Development Award EY034912NEI NIH HHS K08 EY034912Retina Society/International Retinal Research Foundation
6 · The paper itself

Abstract

objectivesThis study aims to develop and evaluate a novel slit-lamp-based system to acquire 3-dimensional (3D) ultrasound volumes using conventional ultrasound probes.

methodsA slit-lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2-dimensional scans. The ultrasound probe contacted the patient's cornea to perform the scan. The GUI software was designed to acquire and process b-scan images, which were exported to 3D Slicer and manually annotated. The annotated images were used to render 3D renderings of ophthalmic anatomy using MATLAB and 3D Slicer.

resultsThe optimal resolution, quality, scan type, and patient comfort were determined through simulations. Higher scan numbers and light contact pressure resulted in sufficient image clarity. Out of 250 completed scans, four 3D ultrasound models were created, depicting diagnoses such as tractional retinal detachment, choroidal hemorrhage, and myopia. These models were compared with traditional imaging methods.

conclusionsThe study successfully created 3D ultrasound scans using a novel slit-lamp-based system and manual annotation. The accuracy of the models was comparable to other imaging forms and demonstrated greater details. This study represents a significant step toward an accessible point-of-care ultrasound system in ophthalmology.

Indexed as

EyeEye DiseasesImaging, Three-DimensionalSlit LampEquipment DesignHumansReproducibility of ResultsUltrasonography3D ultrasound modelingophthalmic 3D ultrasoundophthalmic ultrasoundpoint‐of‐care ultrasoundretinal imaging

Identifiers

PMID41795628
PMCPMC13356307

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.