ArticleAlimentary pharmacology & therapeutics2026
Frailty Is Associated With All-Cause and Acute Hospitalisations During 18 Months Follow-Up in Older Patients With Inflammatory Bowel Disease.
Article in Alimentary pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Frailty Is Associated With All-Cause and Acute Hospitalisations During 18 Months Follow-Up in Older Patients With Inflammatory Bowel Disease.Alimentary pharmacology & therapeutics · 2026Article
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines recommend considering frailty in the management of older patients with Inflammatory Bowel Disease (IBD). A geriatric assessment is a specific and clinically applicable frailty assessment tool that could potentially predict both adverse outcomes and inform treatment decisions in older patients with IBD.
aimsTo examine the association of frailty with hospitalisations and mortality in older patients with IBD during 18 months follow-up.
methodsThis is a prospective, multicentre cohort study in older patients (age ≥ 65 years) with IBD. Frailty was measured using a geriatric assessment, covering five domains of functioning. Deficits in geriatric assessment reflect the level of frailty and were defined as: no deficits (0-1 impaired domains), moderate deficits (2-3 impaired domains) and severe deficits (4-5 impaired domains). Follow-up was aimed at after 18 months. Outcomes were all-cause, acute and IBD-related hospitalisation and mortality. Analyses were adjusted for age, sex and biochemical disease activity (C-reactive protein ≥ 10 mg/L and/or faecal calprotectin ≥ 250 μg/g).
resultsOf 405 patients with median age 70 years, 160 (39.5%) had 2-3 geriatric deficits, 32 (7.9%) had 4-5 geriatric deficits. Severe deficits were independently associated with both all-cause (adjusted hazard ratio [aHR] 3.46, 95% confidence interval [CI] 1.67-7.16) and acute hospitalisations (aHR 3.45, 95% CI 1.59-7.51). Specifically, an impaired somatic domain was independently associated with all-cause hospitalisations (aHR 2.13, 95% CI 1.32-3.42) and acute hospitalisations (aHR 2.43, 95% CI 1.40-4.22).
conclusionsFrailty, reflected by severe deficits in geriatric assessment, is independently associated with all-cause and acute hospitalisations in older patients with IBD.
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