Evidence map›Paper›PMID 41795590›Full record

ArticleCancer medicine2026

Differential Effects of Saturated and Unsaturated Fatty Acids on Colorectal Cancer via IDO1 Signaling.

Shulin Zhang, Jing Zhang, Jiaqi Chen, Abdel Nasser B Singab, Guang Yang, Jiaxuan Li, Peiyao Li, Songlin Wu, Di Zhao, Junhua Sun and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shulin ZhangCheeloo College of Medicine, Shandong University, Jinan, China.
Jing ZhangThe First Clinical Medical College of, Shandong University of Traditional Chinese Medicine, Jinan, China.
Jiaqi ChenCheeloo College of Medicine, Shandong University, Jinan, China.
Abdel Nasser B SingabDepartment of Pharmacognosy, Ain-Shams University, Cairo, Egypt.
Guang YangCheeloo College of Medicine, Shandong University, Jinan, China.
Jiaxuan LiCheeloo College of Medicine, Shandong University, Jinan, China.
Peiyao LiCheeloo College of Medicine, Shandong University, Jinan, China.
Songlin WuCheeloo College of Medicine, Shandong University, Jinan, China.
Di ZhaoCheeloo College of Medicine, Shandong University, Jinan, China.
Junhua SunCancer Center, The Second Hospital of Shandong University, Jinan, China.
Lifen GaoKey Laboratory for Experimental Teratology of Ministry of Education, Shandong Key Laboratory of Infection and Immunity, and Department of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Guimei LinKey Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medience, Shandong University, Jinan, China.
Guanying YuDepartment of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Yanfeng IvDepartment of Colorectal Surgery, the Second Hospital of, Shandong University, Jinan, China.
Hongbo WangDepartment of Gastroenterology, the Second Hospital of, Shandong University, Jinan, China.
Lin YuanDepartment of Colorectal Surgery, the Second Hospital of, Shandong University, Jinan, China.
Lan YeCheeloo College of Medicine, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0003-3735-5844

Funding

Natural Science Foundation of Shandong Province ZR2021MH104Science Fund for Distinguished Young Scholars of Shandong Province tsqn201909178the Cultivation Fund of the Second Hospital of Shandong University 2023JX16the Shandong Medical Association Qilu Medical Special Project YKH2022K02112
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) incidence has risen significantly in China, potentially linked to dietary Westernization and increased consumption of high-fat diets (HFD).

methodsThis study examines the differential effects of various fatty acids-saturated (palmitic acid, PA), monounsaturated (oleic acid, OA), and polyunsaturated (arachidonic acid, AA; docosahexaenoic acid, DHA)-on CRC progression, focusing on the IDO1/AhR signaling pathway.

resultsClinical data indicate that CRC patients exhibit elevated serum lipid levels, with PA promoting cell proliferation, migration, and invasion more strongly than unsaturated fatty acids. The pro-tumorigenic effects of PA are enhanced in the presence of lipopolysaccharide (LPS), suggesting an interaction between diet and gut microbiota. In vivo experiments corroborate that a high-PA diet significantly elevates tumor growth and IDO1 expression compared to DHA. Mechanistic analyses reveal that PA and LPS co-stimulation activates the IDO1-AhR-PI3K/Akt-NF-κB pathway, which is implicated in CRC progression.

conclusionsThese findings suggest that saturated fatty acids, particularly PA, may exacerbate CRC development risk through metabolic dysregulation, highlighting the potential of IDO1 as a biomarker for CRC associated with HFD. Reducing dietary saturated fat intake may thus be a viable strategy for CRC prevention.

Indexed as

Colorectal NeoplasmsFatty AcidsFatty Acids, UnsaturatedIndoleamine-Pyrrole 2,3,-DioxygenaseAnimalsCell Line, TumorCell MovementCell ProliferationDiet, High-FatFemaleGastrointestinal MicrobiomeHumansMaleMiceSignal TransductionFatty AcidsFatty Acids, UnsaturatedIDO1 protein, humanIndoleamine-Pyrrole 2,3,-Dioxygenasecolorectal cancerfatty acidsgut microbiotahigh‐fat dietIDO1

Identifiers

PMID41795590
PMCPMC12967639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.