Evidence map›Paper›PMID 41795500›Full record

ReviewDevelopmental cognitive neuroscience2026

Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.

Paige M Nelson, Dashiell D Sacks, Marta Korom, Nushka Remec, Guy A Perkins, Kevin M Cook, Sally M Stoyell, Megan E Evans, Julia Moser, Chiara Capparini and 7 more

Abstract readReview
In one paragraph

Review in Developmental cognitive neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paige M NelsonStead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: paige-nelson@uiowa.edu.
Dashiell D SacksDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Marta KoromNational Institute of Mental Health, Bethesda, MD, USA.
Nushka RemecNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Guy A PerkinsUniversity of Padova, Department of Developmental Psychology and Socialization, Via Venezia, 8, Padova 35131, Italy.
Kevin M CookDeveloping Brain Institute, Children's National Hospital, Washington 20010, DC, USA.
Sally M StoyellInstitute of Child Development, University of Minnesota, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, MN, USA.
Megan E EvansFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Translational Biology, Medicine, & Health Graduate Program, Virginia Tech, Roanoke, VA, USA.
Julia MoserMasonic Institute for the Developing Brain, University of Minnesota, MN, USA.
Chiara CappariniLaboratoire de Neuroanatomie de Neuroimagerie translationnelles (LN2T), ULB Neuroscience Institute (UNI), Université libre de Bruxelles (ULB), Brussels 1070, Belgium; ULBabyLab, Center for Research in Cognition and Neurosciences (CRCN), ULB Neuroscience Institute (UNI), Université libre de Bruxelles (ULB), Brussels 1050, Belgium.
Sanjana InalaDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Istvan N HuszarAthinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Radiology, Harvard Medical School, Boston, MA 02115, USA.
Michal R ZieffDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Angelina VernettiChild Study Center, Yale School of Medicine, New Haven, CT, USA.
Elizabeth S NortonRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA; Institute for Innovations in Developmental Sciences, Northwestern University, Evanston, IL, USA.
Carol L WilkinsonDivision of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Tomoki ArichiEarly Life Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, UK.

Funding

Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Links between the neonatal connectome and dimensions of social developmentR01MH137609 · NIMH · YALE UNIVERSITY · PI KATARZYNA CHAWARSKA, Laura R. Ment · 2024 to 2026
$2.5M
Continuous longitudinal atlas construction for the study of brain developmentR01HD109436 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Lilla Zollei · 2022 to 2026
$2.2M
fMRI Study Of Risk Of Mood/Anxiety Disorders In ChildrenZ01MH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.7M
Intramural NIH HHS Z01 MH002782NICHD NIH HHS R01 HD109436NIMH NIH HHS P50 MH115716NIMH NIH HHS R01 MH137609NIMH NIH HHS T32 MH019113
6 · The paper itself

Abstract

Over the past decade, fetal, infant, and toddler (FIT) neuroimaging has become a rapidly expanding field, driven by advances in technology and computational methods. By providing non-invasive ways to explore the developing brain in both typical and pathological development, FIT neuroimaging holds promise for advancing pediatric medicine. Magnetic resonance imaging (MRI), ultrasonography, and electroencephalography (EEG) are regularly used in clinical practice to identify or rule out structural brain abnormalities; monitor the timing and evolution of brain injuries; assess brain growth and maturation; diagnose and monitor seizures, including infantile spasms; and facilitate pre-surgical planning. Other methods, including functional MRI, magnetoencephalography (MEG), and near-infrared spectroscopy (NIRS), provide information about brain function but have not yet been considered standard-of-care. As the field has rapidly advanced, numerous barriers (e.g., concerns regarding cost-effectiveness, safety, availability and portability, bedside applicability, suitability for serial imaging, and uncertain predictive utility) have hindered the routine use of neuroimaging techniques. This review focuses on how FIT neuroimaging research can be applied beyond academic settings to improve outcomes in clinical environments, such as high-risk follow-up programs and neonatal and pediatric intensive care units. Key topics include: (1) how FIT neuroimaging can advance pediatric medicine; (2) challenges and gaps in translating FIT neuroimaging to clinical practice; (3) proposed strategies for bridging these gaps; and (4) a framework for clinical translation and future directions to enhance pediatric healthcare and developmental outcomes.

Indexed as

BrainNeuroimagingTranslational Research, BiomedicalChild, PreschoolHumansInfantInfant, NewbornMagnetic Resonance ImagingBrain developmentClinical translationMRINeuroimagingPediatric medicine

Identifiers

PMID41795500
PMCPMC12993157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.