Evidence map›Paper›PMID 41795142›Full record

ArticleCell proliferation2026

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β-Catenin Signalling Pathway in Obstructive Nephropathy.

Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan

Abstract read
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jia WeiDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.ORCID https://orcid.org/0000-0003-3107-5083
Zixia LiDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Gengyu DuDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Ting ChenDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Min YangDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Zhen YuanDepartment of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yidan ZhengDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiang YanDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.ORCID https://orcid.org/0009-0007-9198-9019

Funding

Huadong Medicine Joint Fund of Zhejiang Provincial Natural Science Foundation of China LHDMZ25H050002the National Natural Science Foundation of China 82371709
6 · The paper itself

Abstract

Obstructive nephropathy leads to renal fibrosis, and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) drives this macrophage-mediated process, but its mechanism remains unclear. This study investigated TREM2's role in macrophage polarisation and renal fibrosis progression. In human fibrotic kidneys, TREM2 expression was significantly elevated and co-localised with macrophages. Unilateral ureteral obstruction (UUO) modelling in mice recapitulated this upregulation, accompanied by renal fibrosis, M2 macrophage polarisation and glomerular filtration rate (GFR) reduction. Trem2 deficiency (Trem2

Indexed as

beta CateninKidneyKidney DiseasesMacrophagesMembrane GlycoproteinsReceptors, ImmunologicUreteral ObstructionAnimalsFibrosisHumansMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transductionbeta CateninMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mousemacrophageobstructive nephropathyrenal fibrosisTREM2

Identifiers

PMID41795142
PMCPMC13325555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.