Evidence map›Paper›PMID 41795129›Full record

ArticleNeurogastroenterology and motility2026

National Medical Expenditures Associated With Pediatric Disorders of Gut-Brain Interaction in the United States.

Ayesha C Sujan, Janos Major, Cornelius B Groenewald, Jennifer A Rabbitts

Abstract read
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayesha C SujanDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA.ORCID https://orcid.org/0000-0002-4374-9949
Janos MajorInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.ORCID https://orcid.org/0000-0002-6375-5756
Cornelius B GroenewaldDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
Jennifer A RabbittsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA.

Funding

Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
Sleep deficiency and opioid use/misuse in adolescents following surgeryR01HL166337 · NHLBI · STANFORD UNIVERSITY · PI Cornelius Botha Groenewald · 2023 to 2026
$2.4M
Preventing the Transition from Acute to Chronic Musculoskeletal Pain in Adolescents after Surgery: The Role of SleepK24AR080786 · NIAMS · STANFORD UNIVERSITY · PI Jennifer Rabbitts · 2023 to 2026
$712k
NHLBI NIH HHS R01 HL166337NIAMS NIH HHS K24 AR080786NIAMS NIH HHS K24AR080786NIAMS NIH HHS R01HL166337NIGMS NIH HHS T32 GM089626NIGMS NIH HHS T32GM089626NIH HHS
6 · The paper itself

Abstract

backgroundLimited research has evaluated national medical expenditures associated with pediatric disorders of gut-brain interaction (DGBI), despite the high prevalence of these disorders in children and their association with reduced quality of life.

methodsWe used data from the 2017-2022 Medical Expenditure Panel Survey (MEPS) to estimate the individual- and national-level outpatient, office-based, prescribed medication, emergency room, inpatient, and other medical expenditures, and overall expenditures associated with pediatric DGBI. Pediatric DGBI included International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10) codes associated with irritable bowel syndrome, functional dyspepsia, and other functional intestinal disorders (including constipation) among 40,067 individuals ≤ 18 years receiving medical care in the United States. KEY

resultsAfter controlling for predisposing factors, enabling resources, and co-morbid medical conditions, total per patient annual medical expenditures were $5217 (in 2022 dollars) for pediatric patients with DGBI-an estimate that was $2587 greater than the estimated medical expenditures for children without DGBI. Incremental spending from DGBI patients versus patients without DGBI was highest for outpatient visits followed by office-based visits, prescribed medications, and emergency room visits. Total annual medical expenditures for pediatric patients with DGBI were estimated at $2.08 billion. CONCLUSIONS AND INFERENCES: The results illuminate the significant national medical expenditures associated with pediatric DGBI, suggesting the potential importance of early detection and effective treatment for pediatric DGBI and the need for future research to improve assessment and evidence-based treatment for pediatric DGBI.

Indexed as

Gastrointestinal DiseasesHealth ExpendituresAdolescentChildChild, PreschoolFemaleHumansInfantMaleUnited Statesfunctional gastrointestinal disorderhealth expenditurespediatrics

Identifiers

PMID41795129
PMCPMC12969732

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.