Evidence map›Paper›PMID 41795005›Full record

ArticleHeredity2026

Structural variation in context: mechanisms, functions and selection regimes across the tree of life.

Charikleia Karageorgiou, Ellen M Leffler, Megan Y Dennis, Omer Gokcumen

Abstract readEditorial
In one paragraph

Article in Heredity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charikleia KarageorgiouDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA. charikle@buffalo.edu.ORCID 0000-0002-6998-6926
Ellen M LefflerDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA. leffler@genetics.utah.edu.
Megan Y DennisDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA, USA. mydennis@ucdavis.edu.
Omer GokcumenDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA. omergokc@buffalo.edu.

Funding

Human gene duplications in neurodevelopment and diseaseRF1MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2025 to 2025
$2.1M
Genomic signatures of primate-pathogen interactionsR35GM147709 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ellen Leffler · 2022 to 2026
$1.9M
Human gene duplications in neurodevelopment and diseaseR01MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2023 to 2024
$1.4M
Evolutionary and functional impact of common genomic structural variationsR35GM156519 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Omer Gokcumen · 2025 to 2026
$887k
National Science Foundation (NSF) 2123284National Science Foundation (NSF) 2145885NIMH NIH HHS RF1 MH132818NSF 2049947U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147709U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM156519U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH132818
6 · The paper itself

Abstract

Genomic structural variants (SVs) are central to modern genetics. However, they do not fit easily into the simple classifications and analytical frameworks that work well for single‑nucleotide polymorphisms (SNPs). The papers in this special issue underscore that SVs cannot be treated as a homogeneous class, nor can their evolutionary consequences be inferred directly from their structural category alone. Instead, they compel us to engage explicitly with mutational mechanism, genomic context, and selection regime, and to recognize that the structural category only weakly predicts their functional and evolutionary impact.

Indexed as

Genomic Structural VariationSelection, GeneticEvolution, MolecularMutationPolymorphism, Single Nucleotide

Identifiers

PMID41795005
PMCPMC13031434

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.