ArticleAntimicrobial resistance and infection control2026
Understanding antibiotic prescribing in the inpatient setting: a synthesis of evidence on determinants and interventions.
Article in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Efficacy and safety of Omadacycline in community-acquired pneumonia among elderly patients: a real-world evidence study.Frontiers in cellular and infection microbiology · 2026Article
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10 authors.
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Abstract
backgroundThere is an urgent need to optimize antimicrobial prescribing in the hospitalized setting, driven by the complexity of infection types, the high risk of antimicrobial resistance, and the potentially severe clinical consequences. However, the key determinants of physician prescribing behavior remain inconsistent, and the evidence regarding the effectiveness of interventions is still subject to debate.
methodsWe searched PubMed, Embase, Cochrane Library, and Web of Science up to July 5, 2025, to identify evidence on determinants of and interventions for antibiotic prescribing practices in the inpatient environment. Through a single-arm 3-level model, we quantified the influence of these determinants on prescription behavior. We employed a random-effects model to analyze the effect of interventions on prescription outcomes. Interventions were categorized by behavior change techniques, with the effectiveness rate calculated.
resultsA total of 59 studies were included, comprising 20 qualitative and 39 quantitative investigations. The findings indicated that 77.6%, 71.4%, and 64.2% of participants acknowledged the influence of environmental, prescriber, and patient factors, respectively. Interventions were associated with a 21% (RR = 1.21, 95% CI: 1.03-1.42) improvement in rational antimicrobial prescribing. Analysis of behavior change techniques identified "behavior feedback" as the most effective strategy (effectiveness rate = 3.5).
conclusionOur study shows that hospitalized physicians' antibiotic prescribing is shaped by multiple determinants, with contextual and environmental factors most frequently studied. Interventions generally improved prescribing in hospital settings. However, evidence from resource-limited settings remains sparse; rigorous, context-specific studies are needed to optimize prescribing in low- and middle-income countries.
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