Evidence map›Paper›PMID 41794765›Full record

ReviewBiology direct2026

Circadian rhythms and microbiota: molecular crosstalk and its implications for health and disease.

Guanlin Wu, Jiayang Zhang, Shixian Yan, Na Liu, Weiling Chen, Fenglin Wu, Zining Wang, Junzheng Zhang, Yuzhe Yang, Yunshu Deng and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Guanlin Wu *School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Jiayang Zhang *School of Basic Medical Sciences, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Shixian YanDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Na LiuNeonatology, Weifang Maternal and Child Health Hospital, Weifang, 261000, China.
Weiling ChenSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Fenglin WuSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Zining WangSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Junzheng ZhangSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Yuzhe YangSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Yunshu DengSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Xinyu QiuSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Jiale LiuSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Lingqi ShiSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Xinyu CuiSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Ruohan WanDepartment of Cardiac Surgery, Heart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, 451464, China.
Xingjing LiDepartment of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital & People Hospital of Zhengzhou University, Zhengzhou, 450003, China.
Yongsheng HanDepartment of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital & People Hospital of Zhengzhou University, Zhengzhou, 450003, China. hanyongsheng@zzu.edu.cn.
Guangrui YangSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China. yanggr@sumhs.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythms, evolutionarily conserved 24-hour oscillations, exert precise regulatory control over microbial communities across host niches including the gastrointestinal tract, oral cavity, urinary bladder, and skin. This bidirectional interplay is critical to host physiology: host circadian clocks shape the composition and functional rhythms of resident microbiota, while microbiota-derived signals reciprocally modulate circadian entrainment and tissue-specific rhythmicity. Circadian disruption from shift work, irregular feeding, light pollution, or sleep deprivation trigger microbial dysbiosis and circadian misalignment, contributing to metabolic diseases, gastrointestinal disorders, neuropsychiatric conditions, cardiovascular diseases, and dermatological or reproductive disorders. Mechanistically, this crosstalk is mediated by rhythmic hormonal secretion, microbial metabolites, epigenetic regulation, and immune signaling. Therapeutic strategies such as time-restricted feeding, probiotics, melatonin, and polyphenol-rich diets show promise in restoring temporal homeostasis. This review synthesizes current evidence on circadian-microbiota interplay, elucidates its roles in physiology and disease, and highlights translational opportunities for chrono-microbiome-based interventions to optimize host health.

Indexed as

Circadian RhythmMicrobiotaAnimalsHumansCircadian disruptionCircadian rhythmsHost healthMicrobiotaTherapeutic strategies

Identifiers

PMID41794765
PMCPMC13081592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.