ArticleJournal of nanobiotechnology2026
Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A multifunctional nanotherapeutic strategy based on exosome-liposome hybrid nanoparticles for comprehensive periodontitis management.Journal of nanobiotechnology · 2026Article
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9 authors.
Funding
Abstract
The significant global burden of periodontitis has increased over the past few decades. However, the regeneration and reconstruction of periodontal tissue remain major challenges in clinical practice. Successful periodontal treatment relies on the regulation of calcium signaling. Bone mesenchymal stem cell-derived exosomes (BMSC Exo) hold great potential for promoting calcium influx to enhance osteogenic differentiation, modulate the inflammatory microenvironment, and promote angiogenesis, but their therapeutic efficiency is limited by inadequate stability. To overcome this problem, a mild and facile approach using protocatechualdehyde was employed to modify BMSC Exo (PA@BMSC Exo) through covalent and noncovalent polyphenolic interactions. The resulting PA@BMSC Exo system enhanced the stability against external stress and augmented its ability to induce intracellular calcium entry. Osteogenesis in human periodontal ligament stem cells (hPDLSCs) and integrated periodontal regeneration in periodontitis were observed following PA@BMSC Exo treatment. Furthermore, these multifunctional PA@BMSC Exo also promoted immunoinflammatory regulation and neovascularization. Bioinformatic analysis based on RNA sequencing (RNA-seq) predicted that the osteogenic differentiation of hPDLSCs was enhanced by calcium influx mediated through the voltage-gated calcium channel Ca
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