Evidence map›Paper›PMID 41794733›Full record

ArticleJournal of nanobiotechnology2026

Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis.

Ying Han, Junjie Ren, Yue Su, Linzhu Zhou, Xinyuan Zhu, Zejian Wang, Fei Kong, Guolin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying HanKey Laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, 154000, China.
Junjie RenState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yue SuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Linzhu ZhouSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Xinyuan ZhuSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zejian WangSchool of pharmacy, Shanghai Jiaotong University, Shanghai, 200240, China.
Fei KongCenter for Laboratory Animal Service & Experiments, The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. Drfkong@163.com.
Guolin LiKey Laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, 154000, China. liguolin@126.com.

Funding

National Natural Science Foundation of China 21875134The Introduction of Talent Start-up Funds of Shanghai Eighth People's Hospital 7201
6 · The paper itself

Abstract

backgroundOleanolic acid (OA), a pentacyclic triterpenoid abundantly present in various traditional Chinese herbs, exhibits promising anti-psoriatic potential owing to its broad pharmacological activities. Nevertheless, its clinical translation has been hindered by challenges including poor aqueous solubility, limited cutaneous permeation, and rapid systemic clearance, all of which compromise bioavailability when administered topically. To address these limitations, we designed and developed encapsulated and disulfide bonded OA-hyaluronic acid nanoprodrugs (OA-NPs@OA) for topical treatment of psoriasis in this study.

resultsOA-NPs@OA exhibited significantly enhanced cellular uptake via CD44 receptor-mediated endocytosis in keratinocytes, achieving a markedly lower IC

conclusionsOA-NPs@OA represents a novel targeted nanotherapy that overcomes the limitations of OA in anti-psoriasis by offering enhanced bioavailability, multimodal anti-psoriatic action, and optimized safety profiles.

Indexed as

Drugs, Chinese HerbalHyaluronic AcidNanoparticlesOleanolic AcidPsoriasisAnimalsApoptosisHumansKeratinocytesMaleMiceSkinYAP-Signaling ProteinsDrugs, Chinese HerbalHyaluronic AcidOleanolic AcidYap1 protein, mouseYAP-Signaling ProteinsHyaluronic acidOleanolic acidProdrug nanoparticlesPsoriasisTopical therapyYAP-AREG pathway axis

Identifiers

PMID41794733
PMCPMC12990566

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.