Evidence map›Paper›PMID 41794412›Full record

ArticleImmunity, inflammation and disease2026

Modulation of Cytokines and Immune Cells by Plasma Exchange in Patients With Certain Autoimmune Neurological Diseases.

Wanquan Xu, Shuting Chai, Gang Liu, Fei Tian, Weibi Chen, Dawei Shan, Yan Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wanquan XuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Shuting ChaiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Gang LiuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Fei TianDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Weibi ChenDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Dawei ShanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0005-5216-989X
Yan ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-6615-5329

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2020035China Association for Promotion of Health Science and Technology JKHY2024005
6 · The paper itself

Abstract

objectiveTherapeutic plasma exchange (TPE) plays a crucial role in the management of autoimmune neurological disorders, although its effects on cytokines and immune cells are not fully understood. This study aimed to investigate the impact of TPE on immune cell subsets, cytokine levels, and immunoglobulins.

methodsA total of 85 patients with certain autoimmune neurological disorders underwent TPE, during which laboratory markers and complications were monitored. Blood and cerebrospinal fluid (CSF) samples were collected before and after TPE to assess changes in immunoglobulins, lymphocyte subsets, and cytokines. Clinical outcomes were evaluated 1 month after the TPE course using the modified Rankin Scale.

resultsAmong 408 TPE procedures, complications were mostly mild and manageable, with no fatalities. Peripheral blood leukocyte counts increased significantly, predominantly due to neutrophil elevation. Lymphocyte subset analysis revealed an increase in the proportion of T cells and a decrease in NK cells. Cytokine analysis showed a reduction in serum levels of IL-6 and TNF-α, and a decrease in CSF levels of IL-6, IL-8, IL-10, and IFN-γ. After TPE, immunoglobulin levels (IgA, IgG, and IgM) were significantly lower in both blood and CSF.

conclusionTPE is a safe and well-tolerated procedure for patients with certain autoimmune neurological disorders, potentially promoting recovery by modulating immune cell subsets and clearing pro-inflammatory cytokines.

Indexed as

Autoimmune Diseases of the Nervous SystemCytokinesNervous System DiseasesPlasma ExchangeAdolescentAdultAgedFemaleHumansImmunoglobulinsKiller Cells, NaturalLymphocyte SubsetsMaleMiddle AgedYoung AdultCytokinesImmunoglobulinsautoimmune neurological diseasescytokinesimmunoglobulinslymphocyte subsetstherapeutic plasma exchange

Identifiers

PMID41794412
PMCPMC12967252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.