Evidence map›Paper›PMID 41794294›Full record

ArticleNeurobiology of disease2026

SGK1 inhibition restores excitability of cortical neurons derived from Alzheimer's disease patients.

Zhongjiao Jiang, Komal Saleem, Emily Fisher, Li Li, Zhen Yan, Jian Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongjiao JiangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States.
Komal SaleemDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States.
Emily FisherDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States.
Li LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States.
Zhen YanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States. Electronic address: zhenyan@buffalo.edu.
Jian FengDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, United States. Electronic address: jianfeng@buffalo.edu.

Funding

Transcriptomic and Circuitry Aberrations in Alzheimer’s DiseaseR01AG079797 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JIAN FENG, Zhen Yan · 2023 to 2026
$3.0M
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsR01NS113763 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2020 to 2024
$2.6M
NIA NIH HHS R01 AG079797NINDS NIH HHS R01 NS113763
6 · The paper itself

Abstract

The vast majority of Alzheimer's disease (AD) cases are sporadic, without a clear etiology. We have previously found increased expression of Serum and Glucocorticoid-regulated Kinase 1 (SGK1) in mouse models of dementia, postmortem cortical tissues and induced pluripotent stem cells (iPSCs)-derived cortical neurons from patients with sporadic AD (sAD). SGK1 is induced by a variety of cellular stress. The physiological consequences of elevated SGK1 in sAD is unclear. Here, we differentiated iPSCs from four sAD patients and four age- and sex-matched healthy controls into electrophysiologically mature cortical neurons with prolonged culture for more than 100 days. The sAD cortical neurons exhibited significant reductions in voltage-gated Na

Indexed as

Alzheimer DiseaseCerebral CortexImmediate-Early ProteinsNeuronsProtein Serine-Threonine KinasesAction PotentialsAgedAged, 80 and overCell DifferentiationCells, CulturedExcitatory Postsynaptic PotentialsFemaleHumansInduced Pluripotent Stem CellsMaleSerum-Glucocorticoid Regulated KinasesImmediate-Early ProteinsProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesAlzheimer's diseaseCortical neuronsInduced pluripotent stem cellsNeuronal excitabilitySGK1Synaptic transmission

Identifiers

PMID41794294
PMCPMC13251381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.