Evidence map›Paper›PMID 41794121›Full record

Observational studyChest2026

Evaluating the Association Between Patient Priorities and ICU Care Delivery in Adults Receiving Mechanical Ventilation.

Kara A Donovan, Madison Polley, Geralyn Palmer, Bret M Hanlon, Lily N Stalter, Helen K Donnelly, Richard G Wunderink, Catherine A Gao, Jacqueline M Kruser, NU SCRIPT Study Investigators

Abstract readObservational Study
In one paragraph

Observational study in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kara A DonovanDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin, Madison, WI.
Madison PolleyDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin, Madison, WI.
Geralyn PalmerDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin, Madison, WI.
Bret M HanlonDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI; Department of Surgery, University of Wisconsin, Madison, WI.
Lily N StalterDepartment of Surgery, University of Wisconsin, Madison, WI.
Helen K DonnellyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Catherine A GaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Jacqueline M KruserDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin, Madison, WI. Electronic address: jkruser@wisc.edu.
NU SCRIPT Study Investigators

Funding

Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JUSTIN B. STARREN · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Luisa Morales-Nebreda · 2021 to 2026
$18.9M
CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and LearningU01TR003528 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIMINO, JAMES J, LUO, YUAN · 2021 to 2024
$4.9M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Modeling the Incompleteness and Biases of Health DataR01LM013337 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, YUAN · 2020 to 2023
$1.3M
CHANGE OF GRANTEE INSTITUTION K23 HL146890 A Systems Approach to Align ICU Care with Patient Treatment GoalsK23HL146890 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI KRUSER, JACQUELINE MARIE · 2019 to 2023
$877k
Machine learning to predict cure in severe pneumonia episodesK23HL169815 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Catherine A. Gao · 2024 to 2026
$501k
NCATS NIH HHS U01 TR003528NHLBI NIH HHS K23 HL146890NHLBI NIH HHS K23 HL169815NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NIAID NIH HHS U19 AI135964NLM NIH HHS R01 LM013337
6 · The paper itself

Abstract

backgroundUnderstanding how ICU treatments align with a patient's priorities is crucial to evaluating and improving critical care. Measuring this alignment is challenging, however, because patient priorities evolve over time and are not systematically documented in electronic health records (EHRs). RESEARCH QUESTION: To what extent is ICU care delivery associated with patient priorities, as reported in real time by their surrogate decision-makers? STUDY DESIGN AND

methodsWe conducted a secondary analysis of a prospective observational study of patients who were mechanically ventilated in an adult medical ICU. At study enrollment, surrogates were asked to categorize patients' treatment priorities as: (1) maximize survival; (2) middle ground (try to live as long as possible but with some treatment limitations); or (3) maximize comfort. Demographic characteristics, care delivery, and outcomes were abstracted from the EHR. To evaluate relationships, χ

resultsFor 393 eligible patients, 217 (55.2%) surrogates responded to the patient priorities questionnaire. The most frequently reported priority was middle ground (n = 105 [48.4%]), followed by maximize survival (n = 75 [34.6%]) and maximize comfort (n = 37 [17.1%]). Hospital mortality was similar across groups (35.1% maximize comfort, 34.3% middle ground, and 28.0% in maximize survival; P = .619), as were frequencies of tracheostomy placement, palliative care consultation, and, among decedents, use of life-sustaining therapies near death. A maximize comfort priority was associated with a shorter hospital length of stay in a linear regression model adjusted for age, race, and Charlson Comorbidity Index score (β = -0.43; 95% CI, -0.78 to -0.09; P < .014).

interpretationThis study did not find strong relationships between surrogate-reported treatment priorities and ICU care delivery. These findings underscore the need for ongoing efforts to achieve individualized, goal-concordant care for patients with critical illness.

Indexed as

Critical CareIntensive Care UnitsRespiration, ArtificialAgedFemaleHospital MortalityHumansMaleMiddle AgedProspective Studiescritical caregoal-concordant carepalliative caretreatment priorities

Identifiers

PMID41794121
PMCPMC13105249

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.